Exam 2 Quizlet questions Flashcards
What part of our immune defenses is most associated with neutrophil action?
a. Innate
b. Adaptive
c. Humoral
d. Cell-mediated
innate
Where would you find the most T-cells in the spleen?
a. PALS
b. Follicle
c. Marginal zone
d. Red pulp
PALS
Which of these antibodies is most associated with hay fever allergies?
a. IgA
b. IgG
c. IgE
d. IgM
IgE
What is the role of RAG in antibody function?
a. Templated nucleotide addition
b. Somatic hypermutation
c. Non-templated nucleotide addition
d. Formation of splice junctions
Formation of splice Junctions
What proteins make up the pre-B-cell receptor?
a. Two surrogate chains
b. A light chain and a surrogate chain
c. A heavy chain and a surrogate chain
d. A heavy chain and a light chain
A heavy chain and a surrogate chain
Which of the following skin grafts would fail due to MHC incompatibility?
a. A graft from a b/b homozygous donor to a b/k heterozygous recipient
b. A graft from a b/k heterozygous donor to a b/b homozygous recipient
c. A graft from a b/k heterozygous donor to a b/k heterozygous recipient
d. A graft from a k/k homozygous donor to a b/k heterozygoes recipient
A graft from a b/k heterozygous donor to a b/b homozygous recipient
Which cluster of MHC genes includes complement proteins?
a. Class I
b. Class II
c. Class III
d. None of these
Class III
Negative selection of T-cells occurs when the T cells ___________.
a. Fail to bond to self MHC molecules at all
b. Bind to self MHC molecules with low affinity
c. Bind to self MHC molecules with intermediate affinity
d. Bind to self MHC molecules with high affinity
Bind to self MHC molecules with high affinity
Which of these proteins induces expression of tissue-specific proteins in thymic epithelial cells?
a. RAG1/RAG2
b. Igα/ Igβ
c. AIRE
d. TdT
AIRE
Which of these statements is true of T1 B-cells?
a. They are a special subset of T-cells
b. They are found mostly in the PALS of the spleen
c. They are formed early in the bone marrow
c. They secrete large amounts of antibodies
They are found mostly in the PALS of the spleen
How do T-cell and B-cell development differ?
a. B-cells are negatively selected, but T-cells are not
b. T-cells are negatively selected, but B-cells are not
c. B-cells are positively selected, but T-cells are not
d. T-cells are positively selected, but B-cells are not
T-cells are positively selected, but B-cells are not
What sort of T-cells are most involved in responding to viral infections?
a. TH1
b. TH2
c. TH17
d. TFH
TH1
Which of the following molecules would NOT be found on a cytotoxic T-cell?
a. CD3
b. CD4
c. CD8
d. T-cell receptor
CD4
Which of the following is the best example of a T-independent type I antigen?
a. Lipopolysaccharide
b. Bacterial capsule
c. Secreted proteins
d. Superantigens
Lipopolysaccharide
The presence of IL-4 will bias B-cells to produce more ___________.
a. IgG2
b. IgG1
c. IgA
d. IgM
IgG1
When IL-1 produced at the site of infection results in systemic fever, what sort of action is it?
a. Autocrine
b. Paracrine
c. Endocrine
d. Gap Junction
Endocrine
Which of these cytokines is produced to inhibit viral replication?
a. IL-1
b. TGFβ
c. IL-4
d. Interferon
Interferon
What is the function of C2bC4bC3b in the classical complement cascade?
a. C5 convertase
b. Initiation complex
c. Membrane attack complex
d. C3 convertase
C5 convertase
___________________ is when one copy of a gene is expressed and the other is silenced.
a. Somatic recombination
b. Somatic hypermutation
c. Negative selection
d. Allelic exclusion
Allelic exculsion
Non-templated nucleotide additions to receptor proteins are added by which enzyme?
a. AIRE
b. TdT
c. RAG1
d. AID
TdT
How is MHC diversity generated in a population?
a. Somatic recombination
b. Alternative RNA splicing
c. Somatic hypermutation
d. Codominant expression of polyclonal alleles
Codominant expression of polyclonal alleles
Assume that k/k homozygous mice were infected with a virus and their cytotoxic T-cells were harvested. Which of these conditions would lead to target cell death in vitro when the Tc cells were added?
a. k/k target cells alone
b. b/b target cells alone
c. k/k target cells infected by the virus
d. b/b target cells infected by the virus
b/b target cells alone
Which of these is the correct progression of T-cell development?
a. Double negative -> Single positive -> Double positive
b. Double negative -> Double positive -> Single positive
c. Double positive -> Single positive -> Double negative
d. Double positive -> Double negative -> Single positive
Double negative -> Double positive -> Single positive
T-cell receptor rearrangement occurs primarily in which stage of development?
a. Double negative 1
b. Double negative 2
c. Double negative 3
d. Double negative 4
Double negative 3