Module 22 Flashcards
Changes in Signal Transdustion Pathways
Mutations
Heritable changes in genetic material
They can produce altered receptor proteins that interfere with cell communication
Signalling disruptions
Changes to or replacements for the signaling molecules can interrupt proper cell communication
What can activate inhibit receptors
Chemicals in foods and drugs
What happens when inhibit receptors are attached to the receptor
influence rest of cell response
Abnormal or unexpected responses by the target cell
What happens with cell disruption
homeostasis is disrupted resulting in poor health for an organism
Agonist
any ligand that binds to a receptor and causes a response
Antagonist
any ligand that binds to a receptor and inhibits a response/ transduction pathway
Endogenous ligands
Ligands produced by the body
Exogeneous ligands
Ligands from outside the body
Can affect signaling pathways
Some mimic endogenous ligands, producing typical cell response
Some over-stimulate the signal transduction pathways, resulting in stronger responses
Albuterol
Used to open airways of the lungs
Agonist of the adrenaline receptors
Where is albuterol from
The extract of leaves
What happens when the exogenous agonist of a receptor is bound more tightly
The ligand stays attached longer, resulting in a longer lasting response, and a greater overall response
How can exogenous ligands caused altered cell responses
By coming in the cell at the wrong time, or at the wrong level
Why is caffeine an antagonist
Binds to adenosine receptors but does not cause it change shape and so it remains inactive
It suppresses the response to feel drowsy
Where does aspirin come from
the bark of a shrub called the GENUS SPIRAEA