Module 11: Transplant Immunology Obj. 6, 7 SA

Question 1

3 classifications of graft rejection

Answer 1

hyper acute
acute
chronic

Question 2

Hyperacute rejection

Answer 2

occurs immediately due to pre-existing Ab to the ABO Ag or MHC Class I Ag
Preformed Ab bind complement and lead to vascular damage

Question 3

Acute rejection

Answer 3

occurs within first few days-weeks
Due to activation of T cells in recipient to donor Ag
May be prevented by use of immunosuppressive drugs

Question 4

Chronic rejection

Answer 4

Occurs over long period of time (even years)
Gradual loss of graft tissue structure and function
Both cellular and humoral

Question 5

Graft vs. Host disease

Answer 5

occurs in severely immunocompromised patients

T lymphs from donor tissue recognize Ag of host as foreign and mount an immune response against them

Question 6

Graft vs. host disease can also occur in immunocompetent recipients of blood from a biologically related donor because

Answer 6

the repent will not recognize the donor as foreign, but the donor will see the recipient as foreign

Question 7

Requirement for all direct donation blood products

Answer 7

Blood is irradiated to prevent graft vs. host disease (kills WBC)