Module 11: Transplant Immunology Obj. 4

Question 1

Clinical relevance of HLA system (6)

Answer 1

Natural Function
Anthropology
Paternity testing
Platelet transfusions
HLA and disease susceptibility
Organ, bone marrow, HPC and stem cell transplant

Question 2

Natural function

Answer 2

participation in the recognition of immunogens and regulation of immune response

Question 3

PLT transfusions

Answer 3

HLA class I Ag carried in high concentrations on PLTs
Multiple transfusions = develop Ab to HLA Ag on the transfused leukocytes or PLTs

Question 4

2 problems that HLA Ab may lead to (from recurrent transfusions)

Answer 4

Pt becomes refractory to PLT transfusions because the pats are sensitizes (coated with Ab) and removed rapidly

Non-hemolytic transfusion reaction may occur in response to HLA Ag

Question 5

HLA and disease susceptibility

Answer 5

HLA is a poor presenter of viral/bacterial Ag
Provide poor binding site

In MS and ankylosing spondylitis with high HLA-B7 and HLA-B27, cell mediated immunity is depressed

Question 6

Typing done for kidney transplant

Answer 6

ABO and HLA (A, B, DR)

Recipient checked for existing HLA Ab

Question 7

Typing done for heart and liver transplant

Answer 7

ABO
Physical size compatibility
Seriousness of disease
Finally, HLA match and HLA Ab screen on recipient

Question 8

Typing done for Bone marrow/HPC transplant

Answer 8

HLA match (A, B, DR, DQ)
ABO NOT REQUIRED