Module 11: Transplant Immunology Obj. 1 SA

Question 1

Human leukocyte antigens are called histocompatibility antigens because

Answer 1

they are involved in graft rejection or ocompatibility

Question 2

What are HLA encoded by

Answer 2

MHC genes

3 classes of MHC genes

Question 3

Class I MHC genes

Answer 3

Class I MHC Ag
HLA - A, B, C, (E, F, G)
(cell membrane proteins)

Question 4

Class II MHC genes

Answer 4

Class II MHC Ag
HLA - D: DR, DQ, DO, DM, DP
(cell membrane proteins)

Question 5

Class III MHC genes

Answer 5

Class III MHC Ag
HLA - C2, C4, and BF (factor)
(secreted complement components)

Question 6

Tissue typing usually involves identifying

Answer 6

MHC class I molecules HLA-A and HLA-B
MHC class II molecule HLA-DR

Question 7

HLA antigens serve 2 purposes

Answer 7

Bind to and present foreign antigenic peptides to T cells, thereby initiating the immune response

Distinguish the membrane antigens on a transplanted donor organ/tissue from those of the recipient (initiating tissue rejection)

Question 8

Haplotype

Answer 8

set of alleles (one from each group from each parent)

Question 9

phenotype

Answer 9

a listing of all the alleles identified in an individual

ex. HLA- A5, A2; B8, B51; DR17, DR11.