Misc. - 3

Question 1

how do hypnotic work

Answer 1

modulating gaba

Question 2

which GABA receptors will hypnotic work on?

Answer 2

BZ1 - sedative effects
BZ2- Myoreluxant - anticonvulsant
BZ3- Anxiolytic

Question 3

difference between old benzodiazepine and z- drug binding?

Answer 3

old benzo - all three types of receptors (B1-B3)
z-drugs only B1 (sedative)

Question 4

types of benzo

Answer 4

hypnotic
anxiolytic

Question 5

effect of benzo on sleep

Answer 5

suppress REM

Question 6

common side effects of benzo

Answer 6

numbed emotions
diplopia
muscle weakness
fatigue
ataxia
dizziness
headache
reduce alertness
drowsiness

Question 7

Half life of Diazepin

Answer 7

20-100
20(D)1(i)00zepin

Question 8

Half life of Clonazepine

Answer 8

18-50

colonized in 1850

Question 9

Half life of chlordiazepoxide

Answer 9

5-30

Question 10

Half life of Nitrazepam

Answer 10

15-38
Nitra was 15 when her mom, 38, left her.

Question 11

Half life of Tema

Answer 11

8-22
temam 8-22

Question 12

Lorazepam

Answer 12

10-20

Question 13

ALpra

Answer 13

10-15

Question 14

Oxazepam

Answer 14

6-10

Question 15

Zopiclone

Answer 15

5-6
at zobh (morning) effect is gone

Question 16

Zolpidem

Answer 16

2
Zolm use (arabic)

Question 17

Zaleplon

Answer 17

2

Zalem use (arabic)

Question 18

max duration of benzo Rx

Answer 18

2-4 week

Question 19

tapering recommendation

Answer 19

5-10% every 1-2 weeks
1/8th of the daily dose every 2 weeks

Question 20

pscychological symptoms with benzo withdrawal

Answer 20

anxiety
insomnia
nightmares
depersonalisation
decr. memory and concentration
delusion & hallucination
Depression

Question 21

physical symptoms of benzo withdrawal

Answer 21

stiffness
weakness
GI disturbance
paraesthesia
flu-like symptoms
visual disturbance

Question 22

contraindication of zopiclone

Answer 22

Marked neuromuscular respiratory weakness:

Myasthenia gravis
Resp. failure
Severe Sleep apnoea syndrome
Breast feeding

Question 23

side effect of zopiclone

Answer 23

metalic taste
heartburn
lightening of sleep on withdrawal

Question 24

side effects of melatonin

Answer 24

• somnolence
  Fatigue
  Mood swings
  headache
  irritability
  aggression
  hangover

Question 25

what is daridorexant

Answer 25

orexin receptor antagonist recommended by NICE

Question 26

what receptors daridorexant work on

Answer 26

orexin 1 & 2 receptors

Question 27

what do orexin A &B neuropeptide do naturally?

Answer 27

promote wakefulnesss

Question 28

do daridorexant change sleep cylce proportion

Answer 28

no!

Question 29

contraindication of daridorexant?

Answer 29

narcolepsy

Question 30

daridorexant side effects

Answer 30

somnolence & headache