Meds-Guidlines - 9 Flashcards
what is Tamoxifen?
It is a SERM
Selective Oestrogen Receptor modulator
what is tamoxifen used for?
breast cancer
what cyp450 enzyme metabolizes tamoxifen?
CYP2D6
what antidepressants are known to inhibit CYP2D6?
—Strong inhibitors
Fluoxetine
Paroxetine
Bupropion
Dulexetin
—-Moderate inhibitors
Sertraline
Citalopram
doxepin
which antidepressant is known to be a weak inhibitor of CYP2D6, hence safer with tomoxifen
Venlafaxine
where Topiramte is used?
Epilepsy
Bipolar
Migraine
How does Topiramate work?
It inhibits voltage-gated sodium channels ===>suppresses action potential
It also increase GABA level
what is unusual about topiramate use?
it causes weight loss
psychiatric side effects of topiramate
mood disturbance & depression
medical side effects of topiramate?
kidney stones
are kidney stone dose-dependent side effects of topiramate
yes
how does topiramate causes kidney stones?
the increasing acidity of urine ==>formation of crystal
