Meds Guidline - 10 Flashcards
max dose for clozapine
900 mg/day
max dose for Haloperidol
20 mg/day
max dose for Olanzapine
20 mg/day
max dose for Quetiapine
750 mg for schizophrenia
800 mg for bipolar disorder
max dose for Risperdione
16 mg/day
max dose for Amisulpride
1200 mg/day
max dose for Aripiprazole
30 mg/day
max dose for Flupentixol (depot)
400 mg/day
max dose for zuclopenthixol (depot)
600 mg/day
haloperidol (depot) max
300 mg/day
dose in first vs dose in relapse in schizophrenia for chlorpromazine
200 mg - 300 mg
dose in first vs dose in relapse in schizophrenia for Haloperidol
2 mg - 4 mg
dose in first vs dose in relapse in schizophrenia for Amisulpride
300 mg - 400 mg
dose in first vs dose in relapse in schizophrenia for Aripiprazole
10 mg - 10 mg
dose in first vs dose in relapse in schizophrenia for Olanzapine
5 mg - 7.5 mg
dose in first vs dose in relapse in schizophrenia for Quetiapine
150 mg - 300 mg
dose in first vs dose in relapse in schizophrenia for Risperidone
2 mg - 4 mg
baseline and annual monitoring in schizophrenia
Urea + Electrolytes
FBC
Weight
Glucose
ECG
BP
Prolactive
LFT
Creatine phosphates
monitorings that need to be repeated at 3 month for schizophrenia
weight and blood lipid
monitorings that need to be repeated at 6 months for schizophrenia
prolactin and plasma glucose
extra monitoring for quetiapine
thyroid function test- annually
antipsychotics that cause postural hypotention
PRO-CloZiQue (close to earth)
Paliperidone
Risperidone
Olanzapine
-
Clozapine
Ziprasidone
Quetiapine
antipsychotics to consider if drug-induced postural hypotension is problematic
SHATA (Sat up)
Sulpride
Haloperidol
Aripiprazole
Trifluperazine
Amisulpride
what class causes drowsiness?
histaminergics
What class causes postural hypotention
antiadrenergics
side effects of anticholinergics
dry mouth
constipation
urinary retention
blurry vision
drugs with no anticholinergic effects (postural hypotension)
amisulpride
aripiprazole
asenapine
drugs with most anticholinergic effects
+++ clozapine
++ most 1st generation
drugs with most sedative effects
clozapine +++
Olanzapine ++
drugs with no sedative effects
aripiprazole and amisulpride
drugs with most weight gain effects
clozpaine & olanzapine
drugs with no diabetic effects
aripiprazole
problem with amisulpride
Prolactine +++
best antipsychotics for negative symptoms of schizo
Clozapine
Amisulpride
Olanzapine
1st line antipsychotic for schizoaffective
Paliperidone 3 mg and aripiprazole
True or false?
There is no first-line antipsychotic drug suitable for all people with psychosis, and (except for clozapine) little meaningful difference in efficacy.
True
what about antipsychotics cause weight gain?
5HT2A and 5HT2C antagonist
D2 & D3 Antagonist
H1 and M3 antagonists
Hyperprolactinemia
Increased serum leptin
Ghrelin
GIT enzyme affected by antipsychotic and contribute to weight gain?
Leptin
Ghreline
antipsychotics with most association with weight gain?
CO
clozapine
+
Olanzapine
antipsychotic with no weight gain?
Amisulpride
aripiprazol
asenapine
Haloperidonl
switch to what drugs if weight gain was problematic
LAZ
Lurasidone
aripirazole
Ziprasidone
what medication can help with clozapine induced weight gain
lira glu tide
aripirazole augmentation
