CATIE Study

Question 1

what is CATIE study?

Answer 1

a nationwide study (USA) comparing old and new antipsychotics in schizophrenia

Question 2

surprising results of CATIE

Answer 2

2nd generation antipsychotics are not better than 1st GA regarding EPSEs

Question 3

what antipsychotics were used in Phase I?

Answer 3

ZORQ = Ziprasidone, Olan, Risperidone, Quetiapine
or
Perphenazine (Trilafon)

Question 4

which 2nd GA was better than others?

Answer 4

Olan

Question 5

what happened at phase II?

Answer 5

ones not responded were sent to the efficacy pathway —- clozapine
and
ones not tolerated were sent to the toleration pathway —- Ziprasidone

Question 6

what drug was superior to others in phase II?

Answer 6

Clozapine

Question 7

Normal measures according to NCEP for central obsesity? (metabolic syndrome)

Answer 7

WAIST circumference:

102 cm for males, 88 for female
40 inch males , 36 inch females

Question 8

Normal measures according to NCEP for Dyslipidemia (triglicerides)?(metabolic syndrome)

Answer 8

150 mg/dL or 1.7 mmol/L

Question 9

Normal measures according to NCEP for Dyslipidemia (HDL)?(metabolic syndrome)

Answer 9

40 mg/dl for male
50 mg/dl for female

Question 10

Normal measures according to NCEP for blood pressure?(metabolic syndrome)

Answer 10

135/85

Question 11

Normal measures according to NCEP for Fasting plasma sugar? (metabolic syndrome)

Answer 11

6.1 mmol/L (110 mg/dL)