B12 -cobalamin Flashcards
What is another name for B12
Cobalamin
What age group is more prone to B12 def?
Elderly
Name of commertial B12 form?
Cyanocobalamine
B12 solubility property
Water
Water solubility
Where is b12 observed in GIT?
terminal ileum
how long does B12 def takes to become symptomatic
Several years
Useful measurements to diagnose B12
Homocysteine
Methylmalonic acid
Food sources of B12
Meat
Fish
dairy or food that are fermented
in what type of anemia B12 deficiency is an outcome?
Pernicious anemia (interinsic factor deficiency)
autoimmune atttack on stomach cells that make intrinsic factors which are needed to bind with b12 before it is absorbed
Causes of B12 def
Decr. food intake
Poor absorption
Chronic Pancreatitis
Parasite
Intestinal disease
Metabolic impairment
Example of meds that cause B12 def
Metformin
cholestyramine
Dietary factors cause b12 def
Malnutrition
Vegeterianism
Veganism
Alcoholism
Reduced B12 consumption
Why b12 def is often missed?
Symptoms are non specific
Function of B12
DNA synthesis
Optimal function of Nervous system (myelin formation)
How can b12 def role in DNA synthesis manifest?
Megaloblastic anaemia
General class of symptoms of B12 def
W A I F F
Weakness
Anorexia
Irritability
Fatigue
Failure to thrive
neuropsychiaric class of B12 def symptoms
De - NERVES
De mentia
Numbness (Paressthesis)
Emotional (depression
Reduced coordination (Ataxia)
Visual loss or abnormaity
Enlarged red blood cells and its neurological effects
Siezure
Haematologic class of b12 de symptoms
Macrostatic
Anemia
hyperpigm. neutrophil
Leukopenia
Thrombocytopenia
Pancytopenia
Miscell symstoms of b12
Glossitis
skin hyperpigm.
vomiting
icterus
Can neurologic symptoms of b12 appear without haematologic ones?
Yepppp
Can neurologic symptoms of b12 appear without haematologic ones?
Yepppp
