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ART_MRCPSYCH_B_MENTOR > B12 -cobalamin > Flashcards

B12 -cobalamin Flashcards

1
Q

What is another name for B12

A

Cobalamin

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2
Q

What age group is more prone to B12 def?

A

Elderly

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3
Q

Name of commertial B12 form?

A

Cyanocobalamine

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4
Q

B12 solubility property

A

Water
Water solubility

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5
Q

Where is b12 observed in GIT?

A

terminal ileum

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6
Q

how long does B12 def takes to become symptomatic

A

Several years

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7
Q

Useful measurements to diagnose B12

A

Homocysteine
Methylmalonic acid

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8
Q

Food sources of B12

A

Meat
Fish
dairy or food that are fermented

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9
Q

in what type of anemia B12 deficiency is an outcome?

A

Pernicious anemia (interinsic factor deficiency)

autoimmune atttack on stomach cells that make intrinsic factors which are needed to bind with b12 before it is absorbed

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10
Q

Causes of B12 def

A

Decr. food intake
Poor absorption
Chronic Pancreatitis
Parasite
Intestinal disease
Metabolic impairment

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11
Q

Example of meds that cause B12 def

A

Metformin
cholestyramine

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12
Q

Dietary factors cause b12 def

A

Malnutrition
Vegeterianism
Veganism
Alcoholism
Reduced B12 consumption

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13
Q

Why b12 def is often missed?

A

Symptoms are non specific

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14
Q

Function of B12

A

DNA synthesis
Optimal function of Nervous system (myelin formation)

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15
Q

How can b12 def role in DNA synthesis manifest?

A

Megaloblastic anaemia

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16
Q

General class of symptoms of B12 def

A

W A I F F

Weakness
Anorexia
Irritability
Fatigue
Failure to thrive

17
Q

neuropsychiaric class of B12 def symptoms

A

De - NERVES

De mentia
Numbness (Paressthesis)
Emotional (depression
Reduced coordination (Ataxia)
Visual loss or abnormaity
Enlarged red blood cells and its neurological effects
Siezure

18
Q

Haematologic class of b12 de symptoms

A

Macrostatic
Anemia
hyperpigm. neutrophil
Leukopenia
Thrombocytopenia
Pancytopenia

19
Q

Miscell symstoms of b12

A

Glossitis
skin hyperpigm.
vomiting
icterus

20
Q

Can neurologic symptoms of b12 appear without haematologic ones?

A

Yepppp

21
Q

Can neurologic symptoms of b12 appear without haematologic ones?

A

Yepppp

ART_MRCPSYCH_B_MENTOR (38 decks)

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