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PART ONE REVISION. > MICROBIOLOGY - Fungal Infections > Flashcards

MICROBIOLOGY - Fungal Infections Flashcards

1
Q

What is the mechanism of action of polyene groups (amphotericin and nystatin)

A

Binds to ergosterol and alter’s ionic transport and permeability of cell wall leading to cell lysis.

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2
Q

What is the mechanism of action of imidazole?

A

Inhibition of ergosterol production by affecting the cytochrome p450 pathway

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3
Q

Which imidazole is effective against aspergillus?

A

Itraconazole

Amphotericin (polyene group) is also effective.

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4
Q

What is the main side effect of imidazole ?
What is the main side effect of polyene groups?

A
  1. hepatotoxicity
  2. nephrotoxicity and anaemia
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PART ONE REVISION. (80 decks)

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