MICROBIOLOGY - Fungal Infections Flashcards
1
Q
What is the mechanism of action of polyene groups (amphotericin and nystatin)
A
Binds to ergosterol and alter’s ionic transport and permeability of cell wall leading to cell lysis.
2
Q
What is the mechanism of action of imidazole?
A
Inhibition of ergosterol production by affecting the cytochrome p450 pathway
3
Q
Which imidazole is effective against aspergillus?
A
Itraconazole
Amphotericin (polyene group) is also effective.
4
Q
What is the main side effect of imidazole ?
What is the main side effect of polyene groups?
A
- hepatotoxicity
- nephrotoxicity and anaemia
