GENETICS - Oncogenetics

Question 1

Which mutations causes MEN 2a and MEN2b?

Answer 1

RET proto-oncogene on chromosome 10

Question 2

abl oncogene is associated with what condition?

bcl oncogene is associated with what condition?

hox-11 oncogene is associated with what condition?

Answer 2

1. CML and AML
2. B-cell lymphoma
3. T-cell leukaemia

Question 3

What is c-myc oncogene associated with? (3)

Answer 3

1. breast cancer
2. lung cancer
3. burkitt’s lymphoma

Question 4

What is ras oncogene associated with?
what is ret oncogene associated with?

Answer 4

1. thyroid, colon, lung, pancreas cancer
2. MEN 2A, MEN2B, thyroid carcinoma

Question 5

What is p53? Where is it located?

Answer 5

a tumour suppressor gene located on chromosome 17

Question 6

What is the function of p53? What is it stimulated by?

Answer 6

Holds cell in G1 phase to allow repair of DNA before mitosis. Stimulated by ionising radiation.

Question 7

What are the main proto-oncogenes? (5)

What are the main tumor suppressor genes? (8)

Answer 7

abl, bcl, hox-11, cmyc, ras, ret (5)

p53, Rb, APC, VHL, P16, BRCA 1, BRCA 2, MENIN (8)

Question 8

What is genomic imprinting? Example?

Answer 8

Difference of phenotype expression depending on origin (maternal or paternal) of the disease chromosome

Paternal 15q12 deletion - Prader Willi syndrome

Maternal 15q12 deletion - Angelman syndrome.