MHC- Intro&Class 1 Flashcards
What are the messengers of the adaptive immune system?
MHC molecules
Where do MHC deliver pathogen signals go?
T cells
Who discovered the MHC?
George Snell
What were MHC originally discovered as?
Transplantation antigens
What is a tightly linked cluster of genes whose products play an important role in intercellular recognition and in discrimination between self and non-self
MHC
What molecules are a group of cell surface glycoproteins that deliver invader signals to T cells?
MHC
T/F: Each species has its unique MHC
True
What is the MHC for an equine?
ELA
What receptors recognize an antigen derived peptide that is combined with an MHC molecule on antigen-presenting cells?
T cell
How many classes of MHC molecules are there?
3
What 2 domains form the antigen binding site in MHC 1 molecules?
Alpha 1 and Alpha 2
What type of peptide is present in the MHC class 1?
Antigenic peptide
What type of microglobulin is in MHC 1?
Beta 2
What class of MHC molecules has the following:
Beta pleated sheet as the floor
2 parallel alpha helices as the walls
MHC Class 1
What molecule does the alpha 3 domain of MHC 1 molecules have a binding site for?
CD8
