Lymphocytes- Last Part

Question 1

What is a co-stimulatory receptor and is necessary for naive T cell activation?

Answer 1

CD28

Question 2

What IL receptor is an important growth factor for activated T cells?

Answer 2

IL-2

Question 3

What is the high affinity IL-2R receptor composed of?

Answer 3

Alpha, beta, and gamma chain

Question 4

Lymphocyte surface molecule expression is _________

Answer 4

Dynamic

Question 5

What are the 2 peripheral lymphoid tissues?

Answer 5

Spleen and lymph nodes

Question 6

When does the expression of lymphocyte surface molecules change?

Answer 6

During activation

Question 7

What activates lymphocytes in a non-antigen-specific way?

Answer 7

Lymphocyte mitogens

Question 8

What is used to measure lymphocyte function?

Answer 8

Lymphocyte mitogens

Question 9

Are are obtained from the red kidney bean
Binds N-acetylgalactosamine
Primarily stimulates T cell, slight effect on B cells

Answer 9

PHA

Question 10

Obtained from the jack bean
Binds alpha-mannose and alpha-glucose
Primarily stimulate T cells

Answer 10

Con A

Question 11

Obtained from the pokeweek plant
Acts on T and B cells

Answer 11

PWM

Question 12

From gram-negative bacteria
Primarily stimulates B cells

Answer 12

LPS

Question 13

What 4 things are commonly used mitogens?

Answer 13

PHA
Con A
PWM
LPS

Question 14

What is the 1st signal necessary for T cell activation?

Answer 14

MHC antigen with CD3, CD4/8, and TCR interaction

Question 15

What is the second signal necessary for T cell activation?

Answer 15

CD28 and CD80/CD86 interaction

Question 16

What is the low affinity IL-2R receptor composed of?

Answer 16

Beta and gamma chains

Question 17

During the expression of lymphocyte surface molecule changes during activation:
Naive T cell —> Effector T cells—> _______ ________ and ________ ________ T cells

Answer 17

Effector Memory
Central Memory