Cytokines&Recetors- Receptors Flashcards
Cytokines act through cell ________ receptors
Surface
What receptors consist of at least two functional units, one for ligand binding and one for signal transduction?
Cytokine surface receptors
What type of receptors are found in inflammatory and immune cells but have unclear roles?
Channel-linked receptors
What type of receptors do not serve as cytokine receptors?
Channel-linked receptors
What is an example of a channel-linked receptor?
Ligand-gated ion channel
What are the following examples of:
C5a
Chemokine receptors
Leukotriene receptors
Platelet -activating factor receptor
Immunological receptors
What are membrane bound guanosine triphosphate (GTP) binding proteins?
G proteins
What are receptors that are coupled to G proteins?
Immunological receptors
Receptors use _________ _______ for intracellular signaling?
Tyrosine kinase
Ligation of these receptors triggers activation of the transcription factor NF–kB?
Receptors that activate sphingomyelinase
Receptors that activate sphingomyelinase:
This mechanism of signal transduction is used by which receptor family?
IL-1/toll-like receptor family
Most cytokine receptors act through their intrinsic tyrosine kinases, such as the _________ _______ receptor
Growth factor
Which group of cytokine receptor family is the following:
dimerize in the presence of the ligand
Form complexes of Janus kinases (JAKs)?
Group 1
What do JAKs phosphorylate?
STAT
What dimerizes to form an active transcription factor?
STAT
What group of cytokine receptor family also form heterodimers in the presence of the ligand and signal through the JAK-STAT pathway?
Group 2
Which group of cytokine receptor family binds interferons and members of IL-10 cytokine family?
Group 2
What amino acid phosphorylation is most commonly used in the immune system?
Tyrosine
What do the receptors that activate sphingomyelinase use for intracellular signaling?
Ceramide
The receptors that are coupled to membrane bound GTP binding proteins use ______ ____ to produce intracellular signaling?
Cyclic AMP
