Antigen P&P- DCs Flashcards
DCs are directly from hematopoietic stem cells in the ________ __________
Bone marrow
Newly generated DCs migrate through the body and form networks in virtually every tissue except for ?
Immune-privileged sites
What cells are prominent in lymph nodes, skin, and mucosal surface-sites, where invading microbes are most likely to be encountered?
DCs
What cells might develop into classical DCs when exposed to appropriate cytokines?
Monocytes
What does the state of a DC depend on?
State of Activation
Do DCs have a small or large cell body?
Small, about 13-15um
What are the long cytoplasmic processes on DCs?
Dendrites
The dendrites increase the cell surface area = __________ the efficiency of antigen trapping and maximize contact between DCs and other cell types
Increase
What are the following examples of?
Plasmacytoid DC
Classical DC
Follicular DC
Langerhans cell
Immature DCs
What DC has the following origin:
Bone marrow -> Lymphoid precursor -> Plasmacytic cell
Plasmacytoid DC
What 3 things have the following origin:
Bone marrow -> Myeloid precursor -> Monocyte
Classical and Follicular DCs
Langerhan Cells
What are mouse cDCs?
CD11c+CD123-
cDCs have unique __________
Phenotype
What can monocytes differentiate into depending on the cytokines and cells they encounter?
Macrophages and DCs
What are specialized in taking up, processing, and presenting antigens to naive T cells?
Classical or conventional DCs (cDCs)
What are long-lived cells found in blood, bone marrow, and lymphoid organs?
Plasmacytoid DCs
What DC lacks a myeloid antigens, but retains some lymphoid characteristics?
Plasmacytoid
What are the 2 main surface markers for Plasma- DCs
CD317
Siglec-H
What serves as an early warning system for viral infections since they are rapidly activated by viral nucleic acids?
Plasma DCs
Do Plasma DCs increase or decrease during infection?
Increase
Plasma DCs respond to viruses by synthesizing a large amount of type _ interferons
1
Besides type I interferons, plasma DCs are also major produces for type __ interferons
3
Since Plasma DCs secrete large amount of type 1 interferons (IFN- alphas), what other types of cells do they activate?
Natural Killer (NK) cells
What type of granules do Langerhan cells have?
Birbeck granules
Long dendrites form an extensive network for antigen _________
Capture
What type of DCs are found in the germinal centers of the spleen, lymph nodes, and Peyer’s patches? Also around localized infection sites and chronic inflammatory rxns?
Follicular DCs (fDCs)
What type of DCs are essential for antibody production and the development of B cell memory?
fDCs
What type of DCs capture antigens by phagocytosis, by pinocytosis, and by binding to cell surface receptors?
Immature DCs
Immature DCs kill invaders by mounting a ___________ ______
Respiratory burst
Immature DCs -pH within phagosomes are alkaline. Antigens are not completely degraded, but preserved for presentation by MHC __ molecules
2
What DCs are in response to IL-1, TNF-alpha, PAMPs, and DAMPs?
Activated (mature) DCs
What has the main function to present antigens to T cells, NOT capture antigens?
Activated (mature) DCs
For Activated (mature) DCs-
Cell surface expressions of MHC molecules and ___________ molecules increase
Costimulatory
Where do activated (mature) DCs migrate to?
Draining lymph nodes
Mature dendritic cells= express increases level of surface ____ and ___________ molecules
MHC
Costimulatory
