Complement System- Part 1- Intro&Lectin Flashcards
What depends on:
Antibody in immunized serum which is not temperature sensitive
Complement in all serum which is temperature sensitive
Bacteriolysis
What is a network of interacting pattern-recognition proteins, proteases, serum proteins, receptors, and regulators that kill invaders?
Complement
Complement accounts for _-__% of the proteins in blood serum?
5-10
Complement is heat-____
Liable
What is not active at steady state, but when activated, can create a powerful innate immune response and destroy invaders?
Complement
What 2 things is the complement activated by?
PAMPs or Ag-Ab complexes
What do these 3 pathways make up?
Lectin, Classical, Alternative pathway
Complement
What is the name of the complex that all 3 pathways assemble through a common mechanism?
C5-C9
What pathways are complements activated the most through?
Alternative
Each pathway has its own ______ activation mechanism
Unique
What 2 things can bind to a pathogen surface in order to activate the lectin pathway?
Mannose-binding lectin (MBL)
Or
Ficolin
What part of the lectin pathway has carbon hydrate-recognition domains?
MBL
What part of the lectin pathway has fibronectin domains?
Ficolin
What MASP’s are used in MBL in the lectin pathway?
1,2,3
What MASP’s are used in fibronectin in the lectin pathway?
1 and 2
What is the gerneration C3 convertase also called?
C4b2b
In the generation of C3 convertase, what’s binds to C4b on the pathogen surface?
C2b
During the generation of C5 convertase, what binds to the C3 convertase (C4b2b) on the pathogen surface?
C3b
What is the formula of C5 convertase?
C4bC2bC3b
How many C3b molecules binds to the pathogen surface? 1 or many?
Many
