Cytokines&Receptors- Regulation

Question 1

Resting T cells express few receptors for IL-2, but when activated the expression of these receptors __________ enormously

Answer 1

Increases

Question 2

Receptor antagonist:
IL-1RA is a form of IL-1 that binds to the IL-1 receptor but does not stimulate signal transduction = it _________ active IL-1

Answer 2

Blocks

Question 3

Soluble receptors:
Soluble receptors compete for cytokine binding with the cell surface receptors and hence ______ cytokine activity

Answer 3

Inhibit

Question 4

What are IL-1, 2, 4, 5, 6, 7, 9, TNF-alpha, and M-CSF examples of?

Answer 4

Soluble receptors

Question 5

What plays an important role on the control of inflammatory responses? They act on both the NF-kB and the JAK – STAT pathways?

Answer 5

Suppressors of cytokine signaling (SOCS) proteins

Question 6

IL-1, IL-12, and TGF-beta may bind to ___________ _______ glycosaminoglycans such as heparin or CD44 that serve as reservoir of readily available molecules

Answer 6

Connective tissue

Question 7

Type 2 cytokine IL-4 __________ IgE production, but Type 1 cytokine IFN-y __________ IgE production

Answer 7

Stimulates
Suppresses