Metabolism - Lecture Thirty-Seven Flashcards

Fuel Storage

1
Q

Anaerobic exercise

A

High intensity
Rapid generation of force
Short period
e.g. sprinting and weight-lifting

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2
Q

Aerobic exercise

A

Low intensity
Prolonged, sustained exercise
e.g. long-distance running, swimming and walking

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3
Q

What ways has muscle of regenerating ATP from ADP: anaerobic exercise?

A

Phosphocreatine

Glycogen

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4
Q

What ways has muscle of regenerating ATP from ADP: aerobic exercise?

A

Oxidation of glucose and fatty acids

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5
Q

Phosphocreatine

A

is ‘on site,’ ‘fast fuel.’ There’s about 20 mol per g of muscle and is a high energy phosphate compound

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6
Q

Phosphate

A

Can be transferred to ADP to make ATP

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7
Q

Glycogen

A

is an ‘on-site’ store of glucose in muscle and is mobilised to glucose 1-phosphate by glycogen phosphorylase

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8
Q

Glucose 1-phosphate is converted to

A

Glucose 6-phosphate

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9
Q

Glucose 6-phosphate

A

Fuel for anaerobic glycolysis

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10
Q

Adrenaline binds to beta adrenergic receptors on muscle cells

A

The hormone comes in and binds as an agonist to the receptor in the cell membrane stimulating the mobilisation of glycogen to provide fuel for glycolysis

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11
Q

If the g protein coupled receptor has a GDP

A

It will associate with the receptor AND hormone

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12
Q

GTP

A

Will associate with Adenylase cyclase which makes cAMP from ATP

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13
Q

Anaerobic Glycolysis

A

Muscle glycogen source of fuel. ATP is generated by substrate-level-phosphorylation

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14
Q

Anaerobic Glycolysis: Pyruvate reduced to?

A

Lactate to regenerate NAD+

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15
Q

ATP generation

A

Very rapid but for a short time only

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16
Q

Lactate can cause

A

Muscle pH to drop, therefore causing fatigue

17
Q

What is glycogen mobilisation stimulated by?

A

Ca++ and adrenaline (stress hormone)

18
Q

How is phosphofructokinase activity increased?

A

By allosteric regulators; AMP and Pi

19
Q

Muscle adaptations to endurance training

A

Selective hypertrophy of Type I (aerobic) fibres
Increased number of blood capillaries per muscle fibre
Increased myoglobin content
Increased size and number of mitochondria; increased cristae
Increased capacity of mitochondria to generate ATP by oxidative phosphorylation
Increased capacity to oxidise lipid and carbohydrate

20
Q

Performance enhancing drugs

A

EPO doping - recombinant EPO
Anabolic steroids
Growth factors - recombinant IGF-1, GH