Metabolic Bone Disease

Question 1

How to ask history re: calcium intake?

Answer 1

milk as a kid

Sun exposure

Question 2

range of menopause age?

Answer 2

42-53

Question 3

bone mineral density reference is who?

Answer 3

30 year old healthy woman

Question 4

causes of secondary hyperparathyroidism?

Answer 4

low vitamin D

Question 5

what is serum B-CTX for?

Answer 5

marker for bone resorption
(in kidneys)
diurnal variation

Question 6

P1NP is a marker for what?

Answer 6

bone formation

liver

Question 7

causes of secondary osteoporosis?

Answer 7

corticosteroids
alcohol
smoking
malabsorption
primary, secondary hypodonadism
too much thyroxine

Question 8

therapies for osteoporosis?

Answer 8

HRT
Raloxifene (selective estrogen receptor)
bisphosphonates
teriparatide
denosumab
strontium

Question 9

Raloxifine good for? bad why?

Answer 9

only good for vertebral #

DVTs

Question 10

teriparatide is what?

Answer 10

recombinant PTH given pulsed to stim the osteoblasts

Question 11

denosumab is?

Answer 11

RANKL binder,

6 monthly, subcut

Question 12

denosumab needs what before starting?

Answer 12

normal calcium and vitamin D

Question 13

strontium used for osteoporosis?

Answer 13

not anymore

Question 14

osteomalacia is caused?

Answer 14

vitamin D deficiency

Question 15

adynamic bone disease is?

Answer 15

non active osteoblasts and clasts

Question 16

when to as about mid-thigh pain?

Answer 16

atypical fracture of femur from prolonged bisphosphonates

Question 17

3 ddx for sudden onset back pain in 65 y old female?

Answer 17

disc prolapse
vertebral fracture
bony mets