CNS pathology II

Question 1

GFAP stain is for what?

Answer 1

stains intermediate fibres of glial cells, means it’s more

Question 2

glioblastoma multiforme rx usu.?

Answer 2

temozolomide

radiation

Question 3

common brain tumours

Answer 3

gliomas
meningiomas
acoustic nerve schwannomas
pituitary adenomas

Question 4

where do most tumours occur in kids?

Answer 4

infratentorial or spinal cord

Question 5

NF-1 risk of what tumour?

Answer 5

optic nerve pilocytic astrocytoma

Question 6

rosenthal fibres found in what tumours?

Answer 6

pilocytic astrocytomas

Question 7

types of gliomas

Answer 7

astrocytoma
ependymoma
oligodendroglioma

Question 8

1p19q codeletion in gliomas means?

Answer 8

good survival

Question 9

meningiomas come from? who gets them usually? risk factors?

Answer 9

near dura
middle aged women
NF-2

Question 10

tumours that met to brain are?

Answer 10

lung
breast
renal cell
colorectum
melanoma

Question 11

features of brain abscess

Answer 11

central necrosis, neutrophils

layers of inflamed granulation tissue

Question 12

4 ways you get brain abscess?

Answer 12

direct extension: sinusitis, otitis media, dental abscess
haematogenous - lung, I drug, infective endocarditis
trauma
unknown

Question 13

epidural abscess is usu. what organism?

Answer 13

staph aureus

Question 14

parkinson’s has 2 findings

Answer 14

1. loss of pigmented dopaminergic neurons in substantia niagra
2. lewy bodies

Question 15

environmental factors in parkinson’s?

Answer 15

pesticides

quarry’s

Question 16

toxins for parkinson’s?

Answer 16

MPTP and manganese

Question 17

primary angiitis is?

Answer 17

lymphocytes within the vessel wall, vasculitis

Question 18

features of a high grade brain tumour?

Answer 18

highly dense and cellular and mitotic