Medical SLP - Exam 3 Flashcards
What did VonLangenbeck develop for Laryngectomies?
T-shaped incision and ligature of blood vessels
Incidence v. Prevalence
I: the number of new cases diagnosed within a specific period of time
P: the number of people living with the disease/disorder/etc within a specific period of time
Incidence of Laryngeal Cancer
12,000/year
25% of all head and neck cancers
Incidence and Prevalence of Laryngectomies
I: 5-7,000/year
P: 60,000
Average age of Laryngeal cancer diagnosis
63 years
Normal Cell Circle of Life
- Normal Cell Division
- Gap 1 (shortest gap, 2 hours minimum)
- Synthesis period; DNA replicates
- Gap 2 (10 hours no matter what)
Apoptosis
cell death; normal death at the preprogrammed time so a new cell can take its place
Metastasis
when cancer cells move from the original area (e.g., laryngeal cancer cells move to the lungs). entered lymph or blood systems.
tumor must be 1 gram for detection.
Necrosis
when there is injury or disease that causes cell death
Abnormal cell life (cancer)
when cells don’t have or ignore their suicide program and the immune system doesn’t catch it. Cells go back through the life cycle and duplicates the cancerous cells which replicate more rapidly than normal cells.
cancer cells have _______ _______
genetic defects
What causes cancer?
- inheritance (inherit the tendency to the loss of error control)
- Carcinogens
- Chemicals
- Viruses (HIV, HPV)
- Radiation
Risk factors for laryngeal cancer
smoke, alcohol, poor nutrition and GERD/bulimia
Glottic symptoms of laryngeal cancer
hoarseness, persistent cough, prolonged sore lump in the throat
Sub-Glottic symptoms of laryngeal cancer
dysphagia, persistent throat pain, persistent ear pain, dyspnea/stridor (loud noise while breathing) and unexplained weight loss
T, N, M Laryngeal Cancer Staging
T - Tumor (1,2,3,4 or x)
N - Nodes or neck (0,1,2,3 or x)
M - Metastasis (0 or 1)
Tx Cancer Stage
can’t be diagnosed; can’t accurately assess the staging
T1 Cancer Stage
tumor is in situ (on site), small, on surface. Larynx functionality is fairly normal. Mucosal wave is altered a little, leaving the voice hoarse. No effect on VF movement.
T2 Cancer Stage
tumor is larger and going into the muscle. movement of only the VFs may be slightly affected. voice starting to sound worse.
T3 Cancer Stage
tumor is moving through tissues (muscle and cartilage). effect on laryngeal movement (arytenoids, VFs). voice change. can involve tissues outside larynx (esophagus, tongue, jaw, neck)
T4 Cancer Stage
larynx practically frozen on one side; no movement. arytenoids frozen, no mucosal wave. tumor is large and can involve tissue outside larynx.
N0 Cancer Stage
nodes are not cancerous/malignant
Nx Cancer Stage
can’t be diagnosed; can’t accurately assess the stage
N1 Cancer Stage
ipsilateral side; node involvement (a few nodes are malignant but small). Cancer has entered the lymph nodes.
N2 Cancer Stage
ipsilateral side but more nodes are involved and the tumors are bigger.
N3 Cancer Stage
bilateral node involvement (# of nodes doesn’t matter – critical point: cancer is no longer confined to one side, lymph system is spreading it)
M0 Cancer Stage
cancer has not metastasized
Mx Cancer Stage
can’t be diagnosed; can’t accurately assess the stage
M1 Cancer Stage
cancer has metastasized and gone away from the neck (laryngeal commonly metastasizes to the lungs, sometimes brain)