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Exam 1 Respiration And Immunology Y2 > Medical Microbiology W8 > Flashcards

Medical Microbiology W8 Flashcards

1
Q

Approximate percentage with clinically apparent apparent disease : pneumo cystitis jiroveci

A

0 - if immunity is working well then this won’t make anyone ill

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2
Q

Approximate percentage with clinically apparent apparent disease : EBV (1-5yr old)

A

1 - if get in 20’s could get glandular fever

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3
Q

Approximate percentage with clinically apparent apparent disease : rubella

A

50 - 50:50 chance

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4
Q

Approximate percentage with clinically apparent apparent disease : influenza

A

60

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5
Q

Approximate percentage with clinically apparent apparent disease : whooping, cough, typhoid, malaria, anthrax

A

> 90

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6
Q

Approximate percentage with clinically apparent apparent disease : gonorrhoea (adult male), measles

A

99

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7
Q

Approximate percentage with clinically apparent apparent disease : rabies

A

100 chance

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8
Q

Why do not all infections lead ill illness?

A

Sometimes you can be infected with no signs or symptoms as some aren’t good at making us ill or we have been vaccinated or we have had it before

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9
Q

Routes of transmission people

A

Respiratory or salivary spread - COVID-19

Fecal oral spread - natural disperses ie cholera

Venereal spread - STD

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10
Q

Routes of transmission animals

A

Vector - biting arthropod - mozzie - malaria

Vertebra reservoir - dog to dog to human - rabies

Vertebrae reservoir - tick to mouse to human - plague

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11
Q

Horizontal transmission

A

ie polio

From one person to a group of people by infected air water or food via contact or vectors . Then from that group of people to another group of people.

You can get infected in the week

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12
Q

Vertical transmission

A

ie HIV, HepB

Infected individual passes it along via milk or sperm/placenta to child who then passes it to the next generation and then to the next generation

From parents to children or unborn baby

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13
Q

pseudomonades

A

Is a term for bacteria which morphologically and physiologically resemble members of the genius pseudomonas

They are a very diverse group of Graham rods with strictly respiratory mode of metabolism

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14
Q

Gram-negative Rod

A

Elongated bacteria, which tend to not respond to penicillin and detergents

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15
Q

Importance of pseudomonades of humans

A

They are the quintessential opportunistic pathogen which is a leading cause of hospital acquired infections and develops quite often resistance against antibiotics or detergents

They target weak patient which have weak immune systems or underlining diseases

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16
Q

Whooping cough

A

Bordatella pertussis

A lot in babies - vaccine rates gone down

Produce toxin to interact with Gai protein ad prevent them being active - affect cell signalling in respiratory tract

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17
Q

Legionnaires pneumonia

A

Legionella

Likes warm and moist - taps not been run for a while and the water sits in the tap or air on not cleaned

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18
Q

Gonorrhoea

A

Neisseria gonorrhoeae

causes destructive eye disease transmission is from mother to newborn not just between adults

May not be obvious you have it (no symptoms) but can pass it on

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19
Q

Meningitis x2

A

Neisseria meningitides
Haemophilus influenzae

Doesnt cause influenza. Don’t see a lot in England now

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20
Q

Bubonic plague

A

Yersinia pestis

plague has been responsible for at least 3 great pandemics

• Bubonic plague has a 1-15% mortality rate in treated cases - Infected lymph nodes
• Septicemic plague has a 40% mortality rate in treated cases - Blood infection
• Pneumonic plague has 100% mortality if not treated within the first 24 hours of infection - Droplet transmission

Doesn’t make the animal sick

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21
Q

Lyme disease

A

Borrelia burgdorferi

is spread by bites of ticks three stages of disease:
- distinctive expanding rash at the site of the bite
- dissemination stage with headache and fever
- persistent infection: arthritis, nervous system is affected can be treated with antibiotics

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22
Q

Pneumonia

A

Streptococcus pneumonia

• most common cause of infection-related death in the US and Europe
• caused by a wide range of microorganisms

23
Q

Causes of pneumonia related to age

A

Children
- mostly viral

Adults
- mostly bacterial

24
Q

Endospore forming bacteria

A

• produce a unique resting cell called an endospore, endospores can survive for many years
• Gram-positive and usually rod-shaped
• two important genera are Bacillus and Clostridium
• Bacillus: aerobe

25
Q

Anthrax

A

Bacillus anthracis

disease of cattle that can be transmitted to humans

Anthrax can enter via intestines, lungs and skin

Is non-contageous

26
Q

Cholera

A

Vibrio cholera

Produces toxin (cholera toxin)

Has 2 sub units A and B

Go into GIT cells and replicate and release the toxin here

Toxin then makes it into the cells

Inside cell it binds to GaS

Keeps GaS active to a lot of activating of adenyl cyclase and cAMP production

cAMP leads to activating of CFTR which pumps CL ions out of cell into GIT lumen

Na nad water follow out too nto Lumenso there’s a lot of this in our GIT

= watery diarrhoea

27
Q

pyogenic cocci

A

• spherical bacteria which cause various suppurative (pus- producing) infections in animals
• gram positive cocci are the leading pathogens of humans (around 1/3 of all infections)

28
Q

Staphylococcus aureus

A

lives on skin and nasal membranes, different strains differ in severity of disease they can induce: boils, pimples, wound infections, pneumonia, toxic shock syndrome; leading cause of infections acquired in hospitals, resistant towards penicillin and many other antibiotics

29
Q

MRSA - Methicillin Resistant Staphylococcus aureus

A

usually confined to hospitals, rarely a concern for general public, can be treated by vancomycin (toxic, expensive, has to be given by intravenous infusion)

30
Q

staphylococcal toxins

A

• alpha-toxin: produced by most Staph aureus strains that cause human disease, toxin disrupts the smooth muscle in blood vessels and is toxic to many cell types
• beta-toxin: sphingomyelinase C
• delta toxin: wide spectrum of cytolytic activity
• gamma-toxin
• exfoliate toxin: staphylococcus scaled skin syndrome (SSSS)
• enterotoxins: responsible for staphylococcal food poisoning
• toxic shock syndrome toxin-1: TSST-1: 90% of Staph aureus
strains responsible for menstruation-associated TSS produce TSST-1, death in patients with TSS is caused by hypovolemic shock leading to multiorgan failure

31
Q

Corynebacterium diphtheria

A

• caused by toxin producing C. diphtheria strains
• can cause life-threatening respire
• diphtheria is rare in developed countries, due to immunization
• non-toxigenic strains of bacteria occur in normal pharynx
• bacteria release toxin which destroys epithelial cells
• an ulcer forms which is covered in necrotic exucate (false membrane)
• toxin can cause fatal heart failure
• toxin is absorbed into blood and has several effects
- constitutional upset with fever, exhaustion
- myocarditis
- polyneuritis
• disease is managed by immediate treatment with antitoxin and antibiotic tory obstruction

32
Q

Enterics

A

Interi bacteria are gram-negative rods with facultative anaerobic metabolism that live in the intestinal tracks of animals

typically harmless and help maintain a healthy intestinal environment. However, certain strains of enteric bacteria may be pathogenic, causing illness in humans

Ie E.coli - 2nd important bacteria in the gut and very few strains are pathogenic

33
Q

Bacterial cause of diarrhoea E. coli

A

Enterohaemorrhagic e.coli is verotoxin producing

Outbreak the worldwide

Food and unpasteurised milk

Diagnosis isolate organism from faeces

34
Q

Salmonella

A

Most common cause of food associated diarrhoea and widely distributed in animals for a constant source of infection for humans

35
Q

Diarrhoea from salmonella

A

Salmonella is ingested
It is absorbed into epithelial cells in the small intestine
The bacteria penetrates the cells and migrates to the lamina propria layer of the ileocecal region
Multiply in lymphoid follicles
Polymorphonucleocytes can find the infection to the gastrointestinal tract
Inflammatory response also mediate released a prostate landings
Stimulates CAMP and active fluid secretion
Diarrhoea

36
Q

Top 10 sexually transmitted diseases (organism and disease)

A

papillomavirus - genital warts, dysplasia

Chlamydia trachomatis - non-specific urethritis

Chlamydia trachomatis - lymphogranuloma

Candida albicans - vaginal thrush

Trichomonas vaginalis - vaginitis, urethritis

HSV 1 and 2 - genital herpes

Neisseria gonorrhoeae - gonorrhoea

HIV - AIDS

Treponema pallidum - syphilis

Hepatitis B virus - hepatitis

Haemophilus ducreyi - chancroid

37
Q

spirochetes

A

Very thin, flexible and spiral shaped prokaryotes that move by means of structures called axial filaments

Few pathogens of animals

38
Q

Treponema pallidum

A

Cannot be cultured in self free culture

Syphilis has three stages
-Primary (10 to 60 days after infection)
-Secondary ( last 3 to 6 months)
-tertiary (after 2 to 40 years after infection)

Can be cured with penicillin, chloramphenicol

39
Q

epidemiology and prognosis of syphilis

A

Man is the only known host and transmission

Always by direct contact within infectious lesions generally through sexual contact

Highest in sexually active people 20-29 years

If untreated 25% of people will experience one or more relapse within the first four years

Syphilis is mostly irreversible

40
Q

Chlamydia

A

Chlamydiae are unable to produce ATP in amount required to sustain metabolism outside of the hostel

Chlamydia is the most prevalent sexual transmitted disease but many people show no symptoms of infection

• Chlamydia trachomatis is also a leading cause of blindness
• Chlamydia pneumoniae is a cause of pneumonia

41
Q

Bacterial meningitis (pathogen, host, important clinical features and mortality)

A

Neisseria meningitidis
- children and adolescents
- acute onset (6-24 hours), skin rash
- 7-10%

Haemophilus influenza
- children < 5 years of age
- onset often less acute (1-2 days)
- 5%

Streptococcus pneumoniae
- all ages, but especially children < 2 years of age and elderly
- acute onset may follow pneumonia and/or septicemia in elderly
20-30%

42
Q

Neonatal meningitis

A

At or soon after birth
- Less than seven days old
- Risk factors include pre-term delivery, prolonged labour
- Generalised infection, including meningitis and pneumonia
- 60% fatal
- Treatment is blind

In the nursery
- one week to 3 months old
- Lack of maternal antibodies and or poor hygiene in the nursery
- Predominantly meningitis
- 20% fatal
- Prevention with good hygiene and do not allow mothers to handle other babies

43
Q

Polio virus

A

Wild type polio infections are becoming rarer because of the success of the vaccine

Polio can cause :
- asymptomatic illness which is 90% of infections
- Paralytic polio which can occur in 0.1 to 2% of patients

44
Q

Herpes simplex virus

A

Is it very common virus often resulting in sores or blisters on the skin

Two types :
1) HSV-1 (Herpes Simplex Virus Type 1):
- Commonly causes cold sores around the mouth or on the face.
- Can also cause genital herpes, though less commonly.
- Spread through saliva, kissing, or sharing utensils.

2)HSV-2 (Herpes Simplex Virus Type 2):
- Commonly causes genital herpes (sores on the genitals or rectum).
- Spread through sexual contact.

Infect the skin and nerve cells and can reactivate later

Cure exist but anti-viral medications can manage the symptoms and reduce outbreaks

45
Q

Chicken pox

A

Contagious and caused by the varicella-zoster virus which is a type of herpes virus.
After infection the virus remains dormant in the body and later reactivate as shingles.
Spread through respiratory droplets or direct contact with fluid from the blisters
Extremely contagious

46
Q

Epstein-Barr virus

A

Virus in saliva initiates infection of oral epithelia and spread to B cells in the lymphatic tissue

Virus promote the growth of the cells

T cells kill and limit B cell outgrowth

EBV establishes latency in memory B cell as reactivated when the B cell is activated

47
Q

Measles

A

Highly contagious viral disease caused by the measles virus and can affect anyone at any age if they are unvaccinated or lack immunity

Spread through respiratory droplets and is extremely contagious

48
Q

Site of virus growth for well nourished and malnourished children

A

Lung - temporary respiratory illness - life-threatening pneumonia

Ear - otitis media - more severe otitis media

Oral mucosa — Kopliks spots - severe ulcerating lesions

Intestinal tract - no lesions - diarrhoea

49
Q

Pathogenesis of rubella : site of virus growth, result

A

Respiratory tract - virus shedding symptoms minimal
Skin - rash
Lymph nodes - lymphadenopathy
Joints - arthritis
Placenta/fetus - placentitis, fetal damage

50
Q

Mumps virus

A

Cause of acute benign viral parotitis

Causes lytic infections in cells

Virus replicates first in the respiratory tract

Spread throughout the body to the testes another organs

51
Q

Different hepatitis

A

A - caused by HepA virus typically spread through contaminated food or water and transmission is physical oral route. Only causes acute infection.. improve hygiene and vaccination is available

B - caused by HepB virus which infects liver cells. Transmission is through the blood semen or other bodily fluids. Many are asymptomatic initially. Can be acute or progressive. Chronic vaccination is highly effective and safe sex practices.

C - caused by HepC virus. Primarily spread through blood contact. Transmission is through sharing needles or blood transfusions and many people have no symptoms for years. It frequently progresses to chronic.. vaccine is available

D - caused by HepD virus and can only infect individuals who are also infected with hepatitis B as it requires HBV to replicate. Transmission through blood and bodily fluids.. can be acute or chronic. HBV vaccination directly prevents HDV.

E - caused by HepE virus. Primarily spread through contaminated water via feacal oral root. Mostly acute. In pre-sanitation and access to include water. There is a vaccine but it is not globally available.

52
Q

Hepatitis B virus

A

• small, enveloped DNA virus
• genome is a small, circular, partly double- stranded DNA of 3200bp
• encodes for a reverse transcriptase and replicates through an RNA intermediate

53
Q

Influenza

A

Also known as flu is a contagious respiratory illness caused by influenza virus. Can be divided into four types ABCD.
A causes the most severe epidemic.
B causes seasonal outbreaks

Transmission by airborne droplets and surface contact

Highly contagious

Exam 1 Respiration And Immunology Y2 (62 decks)

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