Colloids WS W4

Question 1

True or flase : Inhalation delivery provides a slower onset of drug action compared to oral delivery.

Answer 1

False - when a drug is inhaled, it is rapidly absorbed through the lungs into the bloodstream, bypassing the digestive system and the first-pass metabolism in the liver. As a result, the drug reaches the systemic circulation much more quickly,

Question 2

True are flase : The choice of excipients in aerosol formulations is primarily determined by the drug being delivered.

Answer 2

F - determined by the delivery of the drug. Somme drugs can have the same excipients

Question 3

True or false : emulsions are more thermodynamically stable than suspensions.

Answer 3

False - emulsions are more prone to phase separation over time due to their higher interfacial energy. Emulsions consist of two immiscible liquids (e.g., oil and water) that are stabilized by surfactants or emulsifiers. On the other hand, suspensions are typically dispersions of solid particles in a liquid

Question 4

True or false : Non-ionic surfactants are generally better emulsifying agents than ionic ones in
pharmaceutical applications.

Answer 4

True - because non-ionic surfactants are less likely to be affected by the ionic strength of the surrounding environment or the pH of the formulation. They tend to form more stable emulsions

Question 5

True or false : The Bancroft rule states that low HLB surfactants are suited for oil-in-water emulsions.

Answer 5

False

Question 6

What is the ideal particle size range for pulmonary drug delivery

Answer 6

1-5 microns

Question 7

What is the primary advantage of using inhalation delivery from drugs like salbutamol

Answer 7

Rapid onset of action

Question 8

What is the primary role of lactose in dry powder inhalers (DPI’s)

Answer 8

Carrier for drug particles

Question 9

Which of the following mechanisms is responsible for the deposition of large particles in
the lungs?

Answer 9

Sedimentation

Question 10

Why are emulsions considered thermodynamically unstable?

Answer 10

over time, they tend to separate into their individual components (i.e., oil and water) due to the difference in their densities

the system would naturally prefer to separate into two distinct phases to minimize the interfacial area between the two liquids

Question 11

What is the role of surface tension in emulsions

Answer 11

Determines the energy cost of creating or maintaining new surface area

Question 12

What is a zwitterion surfactant?

Answer 12

Egg lecithin

Question 13

What does the HLB value of a surfactant indicate ?

Answer 13

Wether its more soluble in oil or water