Asthma Guidelines Workshop W3 Flashcards
How many patients in England with severe asthma aren’t getting the care they need?
Four out of 5
What are the key cell types involved in asthma pathophysiology?
Mast and goblet cells
Which Ga sub unit is couple to the beta two adrenergic receptor airway smooth muscles?
Gas
What class of medicine is turbutaline?
SABA
What is an example of an inhaled corticosteroid?
Budesonide
What drugs could be used as part of the MART regime?
Beclometasone and formoterol
Explain why are you use an agonist at the beta two adrenergic receptor for asthma therapy
It is a GPCR
It is beta 2
It couples to gas
Adenylate cycle converts ATP to cAMP
CAMP binds pKa
CAMP inhibits calcium release which aids in relaxation
Overall, it relaxes and dilates the airways leading to bronco dilation
Explain the rationale for using a long acting bronchodilator for asthma pathophysiology
We use a short acting bronchodilator for the early response and a long acting bronchodilator for the late response as there is two lots of bronchoconstriction
What are some therapeutic monitoring parameters for asthma?
Symptom improvement, breathing better, normally active, more frequent spirometry
What are some toxic monitoring parameters for asthma?
Tremor, palpitations,hypokalemia, mouth irritation
Corticosteroids are used as preventative for asthma treatment. Explain why they are used in reference to early and late phases of asthma.
Early - reduced dendritic cells, reduced mast cells, reduced goblet mucus secretion, reduced endothelial leak, increased beta two receptors
Late - decrease citric and mediators from epithelial cells, reduced cytokines from T lymphocytes and macrophages, reduction in eosinophils and apoptosis
Why would you used inhale steroids over oral dosage forms?
Prevent systemic side effects, mustn’t stop abruptly
