Aaseptic Techniques WS W9 Flashcards
What does ‘HEPA’ stand for?
High-Efficiency Particulate Air.
What is the smallest size of particle that a standard HEPA filter will block?
A standard HEPA filter is certified to capture at least 99.97% of particles that are 0.3 microns (µm) in size
However, HEPA filters can also trap particles smaller than 0.3 microns through additional filtration mechanisms such as diffusion and electrostatic attraction
What is meant by the term ‘turbulent Flow’?
fluid flow characterized by chaotic, irregular motion where the fluid particles move in varying directions,lacks an orderly pattern.
What the problems associated with ‘turbulent Flow’?
Increased energy consumption
Erosions and wear
Inefficient transport of fluids
Particle re suspensions and contamination
Heat loss
What is meant by the term ‘laminar flow’?
fluid flow in which the fluid moves in parallel layers with minimal mixing between the layers.
Each layer flows smoothly, and the motion of the particles within the fluid is orderly and predictable.
typically observed at low velocities
Why is it necessary to have located a LFA cabinet in a room which is
itself a dedicated clean room if used for preparing injections?
ensure the highest level of sterility and contamination control.
What does a ‘pre-filter’ do?
a filtration component designed to capture larger particles and contaminants from air or liquid before they reach the primary filtration system, such as a HEPA filter. Its primary purpose is to extend the lifespan of the main filter and improve overall filtration efficiency.
In which part of the cabinet would you expect to optimise the conditions for
asepsis?
e workspace within the laminar airflow zone, specifically the area directly beneath the HEPA filter
How would you prepare a cabinet before you prepared an injection?
Inspect
Power on
Clean
Gather materials
Decontaminate
Arrange
Conduct
What is likely to disturb the laminar flow conditions?
Blockage of airflow
Turbulence
External air current
How would you minimise turbulence?
Positioning of materials
Unobstructed airflow
Regular maintenance
What is the purpose of testing the inside of the cabinet for:
a) particulates
b) air borne micro-organisms
c) Filter integrity
d) Air velocity
A. Air is free from dust
B. Presence of bacteria for sterile environment
C. HEPA filter functioning properly
D. Measure velocity of airflow
What does the ‘shelf life’ of the made-up injection and/or the length of
time over which it may need to be administered need to be considered?
Stability of active ingredients
Microbial contamination risk
Safety overtime
Duration of administration
Why is the volume of the product needed to be injected/infused a factor?
For the safety and efficacy of the treatment
Volume insures the correct amount of active drug is delivered
Volume can affect the rate of absorption in the bloodstream
Why is the chemical composition (e.g., pH, presence of electrolytes,
sugars and concentration) something that needs to be considered?
They directly impact the stability safety advocacy and compatibility of the product
