Medical Complications Flashcards

1
Q

What hypertensive disorders exist in pregnancy?

A

Chronic (essential ) hypertension
Gestational hypertension
Pre-eclampsia

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2
Q

What is gestational hypertension?

A

New hypertension after 20weeks gestation

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3
Q

What is pre-eclampsia?

A

New hypertension after 20 weeks and significant proteinuria

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4
Q

What other systems does hypertension in preganancy affect?

A

Renal
Liver
Placenta

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5
Q

Hypertensive Effects on renal disease?

A
Decrease GFR
Proteinuria
Increased serum Uric acid
Increased creatinine/ potassium/ urea
Oliguria
Acute renal failure -> acute tubular necrosis , renal cortical necrosis
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6
Q

Hypertensive effects on liver disease?

A

Epigastric / RUQ pain
Abnormal liver enzymes
Hepatic capsule rupture
HELLP syndrome

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7
Q

What is HELLP syndrome?

A

Haemolysis
Elevated liver enzymes
Low platelets

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8
Q

Placental disease due to hypertension?

A

IUGR
Placental abruption
Intrauterine death

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9
Q

Investigations for hypertension?

A
U&Es
Serum urate 
LFTs
FBC
Coagulation screen
CTG
USS
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10
Q

Hypertensive management?

A

BP monitoring

Meds- labetolol, methyldopa, nifedipine

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11
Q

What hypertensive medications are not ok in pregnancy?

A

ACEi

ARBs

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12
Q

What is the target BP for pregnancy?

A

Aim for <150/80-100 mmHg

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13
Q

What effects does pregnancy have on diabetes?

A

Poorer control
Deterioration of renal function
Deterioration of ophthalmic disease

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14
Q

What’s effects does diabetes have on pregnancy?

A
Miscarriage 
Fetal malformations - cardiac, neural tube defects, caudal regressions syndrome 
IUGR/ macrosomnia 
Unexplained IUD
PET
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15
Q

What is the aim HbA1c in diabetes in pregnancy?

A

<6.0%

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16
Q

What is the leading cause of maternal death?

A

VTE in pregnancy

17
Q

What investigation for DVT?

A

Duplex ultrasound of proximal leg

18
Q

Is d dimmer useful in pregnancy?

A

No

19
Q

Management of DVT in pregnancy?

A

LMWH

TEDs

20
Q

Investigations of PE?

A
CTPA
ABGs
CXR
ECG
Duplex US of proximal leg
V/Q scan
21
Q

Can you continue heparin during labour?

A

No

22
Q

Is warfarin safe during pregnancy?

A

Yes but stop 6-12 weeks

23
Q

When do you stop warfarin before labour?

A

6 weeks before

24
Q

Is warfarin safe during breastfeeding?

A

Yes

25
Q

What is hypothyroidism associated with in pregnancy?

A

Increased rates of miscarriage
Still birth
PET
IUGR

26
Q

Treatment for hypothyroidism?

A

Increase levothyroxine

27
Q

What is hyperthyroidism associated with in pregnancy?

A

IUGR

Preterm

28
Q

If hyperthyroid, labour delivery survey and anaesthesia can lead to what?

A

Thyroid storm

29
Q

Management of hyperthyroidism?

A

PTU/ carbimazole
TFTs every trimester
Propranolol
Growth scans

30
Q

Does Epilepsy worsen in pregnancy?

A

Not really, unless already poorly controlled then will deteriorate

31
Q

When are risk of epileptic seizures highest?

A

In peripartum

32
Q

Teratogenic risks of anticonvulsants?

A

Neural tube defects
Orofacial defects
Heart defects
fetal anticonvulsant syndrome

33
Q

What is involved in fetal anticonvulsant syndrome?

A

Dystrophic features - v shaped eyebrows, low-set ears, broad nasal bridge, irregular teeth
Hypertelorism
Hypo plastic nails and distal digits

34
Q

Are antiepileptic drugs safe during labour?

A

Yes

35
Q

What should neonate be given after birth if mum epileptic?

A

1mg IM Vit K

36
Q

Management of epilepsy in pregnancy?

A

Folic acid 5mg /day from 12 weeks prior to conception

Continue drugs if well controlled

37
Q

What antiepileptic drug is not ok during pregnancy?

A

Phenobarbitone