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Repro > Drugs In Pregnancy > Flashcards

Drugs In Pregnancy Flashcards

1
Q

What drugs cross the placenta most quickly?

A

Small lipid soluble drugs

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2
Q

During what period is there greatest teratogenic risk?

A

4-11 weeks

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3
Q

What effect does pregnancy have on plasma volume, and in turn what effect does this have on volume of distribution ?

A

Increased plasma volume which increases volume of distribution

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4
Q

Frequent seizures in pregnancy can have what effect on baby?

A 
Reduced IQ
Hypoxia
Bradycardia
Antenatal death 
Maternal death
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5
Q

Risk associated with taking antiepileptics in pregnancy?

A

Increased risk of congenital abnormalities

Risk IUD

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6
Q

Is insulin safe in pregnancy?

A

Yes

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7
Q

Are sulfonylureas safe during pregnancy?

A

Nooooo

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8
Q

If significant risk factors of VTE in pregnancy, do what?

A

LMWH

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9
Q

What drugs suitable for hypertension In pregnancy ?

A

Labetolol
Methyldopa
Nifedipine

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10
Q

Treat N&V with what?

A

Cyclizine

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11
Q

Treat pain with what?

A

Paracetamol

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12
Q

Treat heartburn with what?

A

Antacids

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13
Q

Treat UTI with what?

A

Nitrofurantoin
Cefalexin
Trimethoprim .

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14
Q

Potential effects of opiates in pregnancy?

A

Respiratory depression

Withdrawal

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15
Q

Potential affects of SSRIs in pregnancy?

A

Withdrawal

NPPH after 20 weeks

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16
Q

What happens to BP in second trimester?

A

It falls

17
Q

Teratogenic drugs?

A 
ACEi/ ARBs
Androgens
Antiepileptics 
Cyctotoxics
Lithium
Methotrexate 
Retinoids
Warfarin
18
Q

What drug is concentrated in Breastmilk?

A

Phenobarbitone

19
Q

What effect may beta blockers have in late pregnancy?

A

They may inhibit fetal growth

20
Q

Drugs to avoid in breastfeeding?

A 
Amiodarone
Cytotoxics
Benzodiazepines 
Bromocriptine
Lithium
Citalopram
21
Q

What affect can amiodarone have on baby?

A

Neonatal hypothyroidism

22
Q

What affect can cytotoxics have on baby?

A

Bone marrow suppression

23
Q

What affect can bromocriptine have ?

A

Suppress lactation

24
Q

Affect of tetracycline on baby?

A

Stains bones and teeth

25
Q

Affect of phenytoin on baby?

A

Cleft lip and palate

26
Q

Affect of valproate on baby?

A

Neural tube defects - Spina bifida, anencephaly

27
Q

Affect of clozapine?

A

Agranulocytosis

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