Drugs In Pregnancy Flashcards
What drugs cross the placenta most quickly?
Small lipid soluble drugs
During what period is there greatest teratogenic risk?
4-11 weeks
What effect does pregnancy have on plasma volume, and in turn what effect does this have on volume of distribution ?
Increased plasma volume which increases volume of distribution
Frequent seizures in pregnancy can have what effect on baby?
Reduced IQ Hypoxia Bradycardia Antenatal death Maternal death
Risk associated with taking antiepileptics in pregnancy?
Increased risk of congenital abnormalities
Risk IUD
Is insulin safe in pregnancy?
Yes
Are sulfonylureas safe during pregnancy?
Nooooo
If significant risk factors of VTE in pregnancy, do what?
LMWH
What drugs suitable for hypertension In pregnancy ?
Labetolol
Methyldopa
Nifedipine
Treat N&V with what?
Cyclizine
Treat pain with what?
Paracetamol
Treat heartburn with what?
Antacids
Treat UTI with what?
Nitrofurantoin
Cefalexin
Trimethoprim .
Potential effects of opiates in pregnancy?
Respiratory depression
Withdrawal
Potential affects of SSRIs in pregnancy?
Withdrawal
NPPH after 20 weeks
What happens to BP in second trimester?
It falls
Teratogenic drugs?
ACEi/ ARBs Androgens Antiepileptics Cyctotoxics Lithium Methotrexate Retinoids Warfarin
What drug is concentrated in Breastmilk?
Phenobarbitone
What effect may beta blockers have in late pregnancy?
They may inhibit fetal growth
Drugs to avoid in breastfeeding?
Amiodarone Cytotoxics Benzodiazepines Bromocriptine Lithium Citalopram
What affect can amiodarone have on baby?
Neonatal hypothyroidism
What affect can cytotoxics have on baby?
Bone marrow suppression
What affect can bromocriptine have ?
Suppress lactation
Affect of tetracycline on baby?
Stains bones and teeth
Affect of phenytoin on baby?
Cleft lip and palate
Affect of valproate on baby?
Neural tube defects - Spina bifida, anencephaly
Affect of clozapine?
Agranulocytosis
