MCN LESSON 1 Flashcards
from ovulation to fertilization
Ovum
rom fertilization to implantation
Zygote
from implantation to 5-8 weeks
Embryo -
from 5-8 weeks until term
> Fetus
developing embryo and placental structures throughout pregnancy
> Conceptus
earliest age at which fetuses survive if they are born; is generally accepted as 24 weeks or at the point a fetus weighs more than 500-600g.
Age of Viability
> first 3 weeks, starting from fertilization
Pre-embryonic Stage
aka CONCEPTION and IMPREGNATION
union of an ovum and a spermatozoon
occurs in the outer third of the fallopian tube (ampullar portion)
only one ova matures each month and is released (ovulation) and if fertilization does not occur within 24-48 hours, it atrophies and becomes nonfunctional
spermatozoon’s functional life is about 48-72 hours
Fertilization is successful in about 72 hours (48 hours before ovulation, 24 hours after)
Mucopolysaccharide Fluid = Zona Pellucida & Corona Radiata {covers the ovum so as to protect it from injury (will develop into placenta,
Fertilization
3 weeks through 8 weeks
Embryonic Stage
Factors affecting Fertilization
matured egg and spermatozoa
able to reach the ovum
able to penetrate the zona pellucida + corona pellucida
contact between the growing structure and the uterine endometrium 8-10 days after fertilization
Implantation
(cluster of cells formed by the ovum as it travels from the fallopian tube) - immediately burrows deeply into the endometrium and establishes an effective communication network with the blood system of the endometrium (inner lining of the uterus)
blastocyst
once implanted, zygote becomes ______
embryo
small amount of vaginal spotting appears on the day of implantation because capillaries are ruptured by the implanting
trophoblast
serves as the fetal lungs, kidneys, and digestive tract in utero
helps provide protection for the uterus; begin growth in early pregnancy in coordination with the embryo growth
i. placenta and membranes
influences the continuous function of the corpus luteum (appears right after egg is fertilized) after fertilization
causes uterine endometrium to continue to grow in thickness and vascularity instead of shedding off as in menstruation
ii. decidua/uterine lining
miniature villi like probing fingers — reach out from the trophoblast cells into the uterine endometrium to begin formation of the placenta ( 11th-12th day after fertilization)
has central core consisting of connective tissues and capillaries surrounded by a double layer of cells; produce various placental hormones
iii. chorionic villi
second function protects the embryo and fetus from certain infectious organisms such as spirochete of syphilis in early pregnancy; disappears after 20th-24th week of pregnancy
appears to have little protection against viral invasion
iv. cytotrophoblast (Langhan’s layer)
grows from few identifiable trophoblastic cells from the beginning of pregnancy to an organ 15-20 cm in diameter, 2-3 cm depth covering half the surface area of the internal uterus at term
COTYLEDONS - maternal portion of the placenta that is rough
at term placenta weighs about 400-600g (1lb) or 1/6 the weight of the baby
a smaller placenta means circulation to the fetus must have been compromised and a bigger placenta means that circulation to the fetus was threatened
i. placenta (latin: pancake)
serves as the source of oxygen and nutrients of the fetus
ii. endocrine system
first placental hormone produced
found in maternal blood and urine as early as the first menstrual period shortly after implantation
fail-safe measure to ensure the corpus luteum continues to produce estrogen and progesterone so the endometrium is maintained and after the 8th week hCG production decreases
human chorionic gonadotropin (hCG):
hormone that maintains pregnancy as well as the endometrial lining during pregnancy and reduces contractility of the uterus reducing premature labor
Progesterone
woman’s hormone and contributes to the mammary gland development
estrogen:
hormone promoting growth and lactogenic properties
produced by the placenta on the 6th week increasing to a peak at term
regulates maternal glucose, protein and fat levels
human placental lactogen:
plasma protein produced by the placenta
contributes to decreasing the immunologic impact of the growing placenta
helps prevent hypertension of pregnancy
placental protein:
(outermost fetal membrane)
formed from the chorionic villi
chorionic membrane
(inner layer):
produces amniotic fluid
no nerve supply
produces a phospholipid that initiates the formation of prostaglandins which may trigger labor
amniotic membrane/amnion
shield the fetus against pressure of the mother’s abdomen
protects the fetus from changes of temperature
aids in muscular development
allows the fetus freedom to move
protects the umbilical cord from pressure
amniotic fluid:
formed from the fetal membranes, amnion and chorion
provides circulatory pathway that connects the embryo to the chorionic villi of the placenta
transport oxygen and nutrients to the fetus from the placenta
iv. umbilical cord
gelatinous mucopolysaccharide
bulk of the cord; protects the umbilical cord’s arteries and vein
Wharton jelly: