Male repro pharm

Question 1

GnRH analog that inhibits testosterone secretion

Answer 1

Leuprolide

Question 1

PGE1 analog

PDE5 inhibitors

Answer 1

PGE1 - Alprostadil

PDE5 - sildenafil

vardenafil

tadafil

Question 2

17-alplha alkylated testosterone, impedes hepatic catabolism

Answer 2

stanozolol

Question 2

mechanism stanozolol

side effect

Answer 2

17-akpha alkylated testosterone, retards hepatic catabolism

hepatotoxicity

Question 4

external/internal genitalia

hair follicles,

erythropoiesis

regulated at

Answer 4

androgen receptor

Question 4

PDE5 inhibitors mechanism

side effects + duration

Answer 4

PDE5 inhibitors - enhances concentration of cGMP (formation stimulated by NO) by inhibiting breakdown

Sildenafil (5h)- headache, flushing, bluish vision (PDE6)
Tadalfil (36h) - headache, dyspepsia, back pain
Vardenafil - headache, flushing

Question 6

catalyzes Testosterone to DHT

Answer 6

5 alpha reductase

Question 7

mechanisn, flutamide

indications

side effects

Answer 7

nonsteroidal competitive inhibitor of androgen receptor

metastatic prostate cancer, hirsutism in women

hepatic failure side effect

Question 7

mechanism, Alprostadil

indications

side effects

Answer 7

PgE1 analog

injection or supository for ED

penile pain, urethral burning

Question 9

other uses of androgens

Answer 9

muscle wasting in AIDS

blood dyscrasias - adjunct in anemia, TTP

angio edema (stanozolol) stimulate hepatic release of C1-esterase inhibitor

endometriosis and fibrocystic breast disease

anabolic steroids

Question 10

finasteride mechanism

indications

side effect

Answer 10

5 alpha reductase antagonist,
reduces T > DHT, especially in external genitalia

BPH, male pattern baldness

impotence, decreased libido

Question 11

non-steroidal, competitive inhibitor of androgen receptor

Answer 11

flutamide

Question 11

PDE5 inhibitors

Answer 11

Sildenafil

vardenafil

tadalafil

Question 13

mechanism leuprolide

indications

Answer 13

GnRH analog

inhibits LH secretion > stimulation of gonadotropin >

> leads to down regulation of GnRH reeeptor > inhibits gonadotropin secretion, > inhibits T secretion

advanced prostate cancer, endometriosis, central precocious puberty

Question 14

adverse effects of androgen ause

Answer 14

1. decreased sperm production, testicular atrophy, sterility

2, high doses > erythrocytosis

3. Gynecomastia
4. 17-alkylated T decrease HDL, increase LDL
5. stunting of linear growth

Question 15

androgen receptor antagonists have limited efficacy becasue

work-around =

Answer 15

increase LH secretion

admin with GnRH analog

Question 16

contraindications for PDE5 inhibitors

Answer 16

pateints taking nitrates (greatly increases action of NO)

Question 17

mechanism cypionate

Answer 17

slow release testosterone

esteryied fatty acid to 17 hydroxyl group makes lipophilic > ester hydrolysis is slow

Question 19

slow release testosterone

Answer 19

cypionate

Question 20

epiphyses,

bone density

lipido

regualted at

Answer 20

estrogen receptor

Question 21

5a-reductase antagonist

Answer 21

finasteride

Question 22

testosterone precursors popular as supplements

Answer 22

androstenedione

DHEA