Female path

Question 1

endometritis histo

Answer 1

plasma cells in endometrial stroma

Question 2

mutations common in endometrial polyps

Answer 2

6p21

Question 3

endometriosis presentation

Answer 3

cyclic bleeding

possible progression to chocolate cyts

blood leads to reactive changes, fibrosis, adhesions

Question 4

endometriosis histo

Answer 4

endometrial glands + stroma

+ / - hemosiderin

Question 5

adenomyosis =

histo

Answer 5

growth of endo metrium in myometrium > enlarged, nodular, abnormal bleeding

Question 6

endometrial hyperplasia due to

histo

Answer 6

prolonged exposure to estrogen - obesity, anovulation, estrogen producing tumors

exagereated endometrial proliferation, glands:stroma >50%
abnormal gland architecture

Question 7

endometrial adenocarcinoma histo

Answer 7

back to back glands
cellualr atypia
abunant mitoses
necrosis

Question 8

mutation in type 1 endometrial adenocarcinoma

Answer 8

mismatch repair gene HNPXX tumor supressor gene PTEN (Cowden sydrome)

Question 9

type II endometria carcinoma histo+ findings

Answer 9

atrophic background

older women, more agressive
independent of endo hyperplasia

atrophic glands

Question 10

leiomyma presentaion and histo

Answer 10

asymptomatic or abnl bleeding
blacks>white
monoclonal prolif of smooth muscle
sharply demarcated

Question 11

leiomyosarcoma histo and presentation

Answer 11

solitary, recurrence and metatasis common (pelvis, lung, bones)

post menopausal

denovo from myometrial mesenchymal cells
soft, hemorrhagic necrotic mass
cytological atypia and mitosis