Cervix vagina vulva path

Question 1

lichen simplex chronicus

Answer 1

secondary to chronic inflammation and itching

thikened hyperketatoic and white plaques

thikened epithelium with chronic inflammation

NO known prediliction for carcnoma

Question 1

invasive sqaumous cell carcinom of vaginaa preceded by

Answer 1

vulvar dysplasia (VIN)

reactive changes (lichen sclerosus)

Question 1

HPV vaccine makeup

Answer 1

HPV l1 protein, th major capsid protein of HPV

Question 3

sqaumocolumnar junction =

Answer 3

trasnformation zone

Question 4

vulvar intraepithelial neoplasia (VIN) =

Answer 4

precancerous lesion of vulva

high risk HPV

(VIN 1-3 depending on dysplasia)

progression to squamosu cell carcnionma

Question 4

sqaumous cell dysplasia of vagina =

Answer 4

VAIN (1-3)

possible porgression to squamous carcinoma

Question 4

quadravalent HPV vaccine covers

Answer 4

6 11 16 18

Question 5

extrammammary paget’s disease =

Answer 5

red scaly plaques on labia

characterized by large pale glandular cells in epidermis

Question 6

dysplaysia in CIN characterized by

Answer 6

nuclear atypia

ncreased N:C ratio abundant mytoses

Question 7

cervical pap smear cytology screening begins at

Answer 7

21

cotesting with/without HIgh risk HPV after age 30

Question 8

endocervical polyps morphology

Answer 8

glandular or metaplastic squamous lining

dilated glands with mucus

may blled (ulceration or infalmmation)

no malignnat potential

Question 8

Answer 8

Question 9

Answer 9

Question 10

sarcoma botryoides (embryonal rhabdomyosarcoma) presentation and appearance

Answer 10

infants and young children

soft, polypoid masses in vagina

urinary bladder and bile ducts also possible

characterized by primitive cells

Question 12

HPV pathogenesis

Answer 12

squamous cell strains replicated DNA ? express E6 and E7

E6 binds p53, E7 binds Rb > promote growth and carinogenesis

Question 13

cervical polyps arise from

characterized by

Answer 13

arise from endocercvical glands

characterized by glandular or metaplastic squamous epithelium

Question 15

ecto cervix epithelium

Answer 15

stratified squamous nonkeratinized

Question 17

CIN is caused by ___

divisions of CIN

Answer 17

preceded by HPV

C1 - basal 1/3 of epeithelium dysplastic

CIN 2 = 2/3

CIN 3 = full thickness

Question 18

carcinomal arising in endocervical glands

Answer 18

adenocarcinoma

Question 20

vulvar strucutres that secerte mucus

Answer 20

bartholin’s glands

Question 21

vulvitis =

Answer 21

infection from bacterial, fungal or viral

nonspecific chronic inflammation of mucosal surfaces )vulvar vestibulitis)

Question 22

Lichen sclerosus =

Answer 22

premenarchal and post menopausal age group

pruritc and thin papery skin

fibrotic dermis, loss of skin appendages, chronic inflam infiltrate

possible development of squamous cell carcinoma

Question 23

clear cell carcinoma associated with

Answer 23

maternal DES expsoure

Vaginal adenosis can progress to clear cell carcinoma