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Endocrine > Breast Dx+neoplastic breast > Flashcards

Breast Dx+neoplastic breast Flashcards

1
Q

medullary carcinoma micrscopy

A

syncytial growth pattern

high nuclear grade

lymphoplasmacytic infiltrate

pushing, nonifiltrative border

ugly cells oftenin sheets

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1
Q

colloid (mucinous) carcinoma presetation

A

postmenopausal

slow growing

axillary metastases

slightly higher in BRCA1

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2
Q

most common regions for carcinoma

A

upper outer

sub areolar

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2
Q

4 molecular subtypes of carcinoma of breast

A

Laminal A

Luminal B (poorer prognosis)

HER2 psotive

Basal like (triple negative)

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3
Q
A

comedo carcinoma in situ

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4
Q

tubular carcinoma microscopic findings

A

single later of eptihelail cells linging glands

no myoepithelail layer

glands scattered in desmoplastic stroma

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5
Q

gynecomastia morpholgy

A

subareolar mass possible

periductal hyaline, collagenous tissue

epithelial hyperplasia of ducts

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6
Q

ductal carcnimoma in situ histopathoogical types

A

Comdeo

Non-comedo

(cribrifomr, micropapillary, papillary, solid, flat/clinging)

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7
Q

most important prognostic factor for invasive carcinoma in absence of distant metastases

A

axillary node status

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8
Q

Oncotype=

A

applicable for pt with early carcinoma, small, node negaative, ER+

expression of a set of genes predictsresponse to chemo

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9
Q

invasive lobular carcinoma microscopic features

A

small cells

single file pattern or targettoid pattern

no glands

intracytoplasmic mucin vacuoes

signet ring cells

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10
Q

invasive lobular carcinoma presentation

metastasis pattern

A

often postmenopause,

multicentric

often contralateral carcinoma (previous or lateer)

metatases: CSF, serosal surfaces, GI, Ovary, uterus, bone marrow

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11
Q

inflammatory carcinoma presentation

A

erythema

peau d’orange

induration of parenchyma

thickening of skin

lymphatic tumor emboli

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13
Q

non-comedo varieties of DCIS

A

cribriform

solid

papillary

micropapillary

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14
Q

medulalary carcinoma mutation

A

increased with BRCA1

does not overexpress Her2/Neu,

negative for ER/PR

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15
Q

colloid mucinous carcinoma mamogram, gross, microscopy

A

well circumscribed and lobulated

soft, pale blue gelatinous surface

cells nested in pools of mucin

16
Q

male breast carcinoma presentation

A

discharge

axillary lymph imvolvement at presentation in half of cases

distant metatases > lungs, brain, bone ,liver

prognosis and treatment the same as in women

17
Q

gynecomastia seen in

A

Klinefelter XXY

Cirrhosis

Alchol, marjuana, anabolics

functionign testicular tumor

19
Q

most common histologic types of breast CA

A

ductal carcinoma in situ

lobular carcinoma in situ

invasive carcinoma - non specified

20
Q

risk factors male breast carcinoma

A

1at degree relative

decreased teseticualr fucntion

epxposure to exogenous estrogens

increasing age, infertility, obesity

BRCA2 mutation

21
Q

prognostic lab markers

A

estrogen receptor

progesterone receptor

HER2Neu FISH/IHC

22
Q

tubular caarcinoma mammogram, gross, presentation

A

40s

multifocal, peripheral breast

mam: small stellate lesion in asymptomatic woman

gray, white, firm

23
Q

medullary carcinoma mammogram and gross

A

mam: oval circumscribed mass

often mistaken for fibroadenoma

gors: soft, fleshy, lobulated bulging cut surface

24
Q

pagets disease of the ipple =

presentation and histo

A

DCIS extending to nipple and areola

ulcerated exzematous skin

carcinoma cells in epidermis

usually high grade or comedo type

25
Q

mammography and gross features invasive lobulaar carcinoma

A

mam often negative, asymmetric, ill defined

spiculated mass/density

gross: hard, irregular bordders

blends to surrounding tissue

26
Q

invasive ductal carcinoma histo and associations

mutations

A

majority of carcinomas

range of features

firm, white masses with distinct borders

usually with DCIS

2/3 ER/PR, 1/3 overexpress Her2/Neu

27
Q

invasive ccarcinoma presentation and mammogram

A

paloable mass

dimpling

retraction of bipple

mass , density or caclifications on imaging

28
Q

Lobular carcinoma in situ presentatoin

A

44-54

often multicentric, bilarteral

rare calcifications

no density/mass

Endocrine (45 decks)

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