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Endocrine > Breast Path > Flashcards

Breast Path Flashcards

1
Q

apocrine cyst morphology

A

large cystic areas

2 layer epithelium

apocrine metaplasia

may have calcifications

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1
Q

presentation papilloma

A

any age

many centrally located

discharge common, bloody in many

subareolar mass possible

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1
Q
A

Atypical ductal hyerplasia

atypical lobule hyperplasia

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2
Q

malignant phyllodes tumor features vs benign

A

marked stromal cellualrity

increased mitoses

cellular pleomorphism

iniltrating border

necrosis

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3
Q

lesions with moderately increased risk and signifcantly increased risk for invasive carcinoma

A

atypical ductal hyperplasia

atypical lobular hyperplasia

DCIS (ipslateral breast)

LCIS (both)

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3
Q

phyllodes tumor histo

A

circumscribed but not encapsulated

interlacing celfts

necrosis and hemorrhage due to rapid growth

leaf-like or epithelium lines clefts or cysts

incresaed stromal cellularity with overgrowth

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4
Q

three manjr influences for devleoping breast carcinoma

A

genetic changes (HER2/Neu, BRCA1 BRCA2)

hormonal

environmental

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5
Q

stromal tumors

A

fibroadenoma

phyllodes tumor

sarcomas

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6
Q

proliferative breast disease without atypia =

Ecamples

A

mammographic densities

califications

moderate florid hyperplasia

sclerosising adenosis

complex sclerosing lesions

papillomas

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7
Q

Clinical presentation of breast disease

finding most consistent with cancer

A

pain

papable mass

nipple discharge or skn changes

lumpiness or other

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7
Q

phyllodes prognosis

A

benign - recur often, but stay benign

low grade - recur, rarely metastasize

high grade - aggressive, often distant metastases, often axillary node

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9
Q

periductal mastitis

A

keratin plug - sup nipple nodule

may be painful if infected > abcess

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9
Q

side effects Tamoxifen prophylaxis breast caricinoma

A

venous thromembolicism

endometrial cancer

cataracts

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10
Q

clincial presentation complex sclerosing lesion

A

40-60y

rarely palpable, detected by mammography

stellate or spiculated lesion with central core

complete excision warranted after biopsy

(hyalainezed stroma with entrapped glands, dialted ducts at periphery)

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11
Q

fat necrosis typically due to

A

trauma

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13
Q

breastmrophology neonatal

pubretal

A

neonatal - ducts,no lobules, 3 layer epithelium

pubertal - lobular unit develops

14
Q

most common lesion by age group

15-25

25-35

35-50

50+

Pregnant or lactating

A

15-25 Fibroadenoma

25-35 Fibroadenoma (cyst or CA rare)

35-50 Fibrocystic changes, CA, cyst

50+ CA until proven otherwise

Pregnant or lactating - lactating adenoma, cyst, mastitis, CA

14
Q

lesions indicated no incresed risk for invasive carcinoma

A

adenosis

fibroadenoma

fibrosis

hyperplasia without atypic

cysts

apocrine metaplasia

16
Q

papilloma histo

A

branching fibrovascular cores within a duct

epithelial hyperplasia often present (more than 2 layers)

18
Q

presentation non-prolifeerative changes (fibrocystic

A

Premenopausal 30-50

lumpy breast, mass, caclifications discharge

pain

multiple or bilateral, flucate in size

19
Q

“triple test”

A

self exam

radiology

biopsy

if 1/3 is suspcisious, rebiopsy

20
Q

fibroadenoma histolgy

A

overgrowth compresses ducts to slit like psaces

21
Q

phyllodes tumor presentation

A

5-6th decade, latin women increased risk

discrete, palpable mass

rapid growth

22
Q

Risk factors breast carcinoma

A

early menarch/late menopause

first live birth later 35y

1st degree relative with CA (only 13%)

24
Q

fibrocystic changes examples (non-proliferative)

A

cysts

fibrosis

apocrine metaplasia

25
Q

lesions with slighlty increased risk for carcinoma

A

complex fibroadenoma

florid hyerplasia without atypia

sclerosisng adenosis

solitary papilloma

26
Q

sclerosing adenosis histo

A

enlarged lobule, cicumscribed edge

preserved architecture

compresse+distorted acinin

dense stroma w/ calcifications

28
Q

suspicious mamogram findings

A

density

microcalicfications

29
Q

acute mastitis

A

infection typically younger, lactating women

Staph Aa. infection

often bilateral

30
Q

preesentation fibroadenoma

A

young adults

solitary, well circumscribed

painless and movable

multiple

regress during menopause

31
Q

indications for breat MRI

A

preop eval of exten of malignant disease

evaluate tumor response to neo adjunvatn chemo

axiallary lymph node pos for metastatic carcinoma with unkonwn primary

evaluate integrity of implant

high risk screening

Endocrine (45 decks)

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