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Endocrine > GU infxn > Flashcards

GU infxn Flashcards

1
Q

treatment herpes

A

famciclovir nucleoside anlogs

(processed by viral but not host DNA polymerase leading to chain termination)

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2
Q

congenital syphyllis does not damage fetus until ____

A

4th month (Abx can prevent)

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3
Q

treatment mollucscum contagiosum

A

scraping, liquid N, iodine

ritonavoir or cidofovir in immunocompromised patients with dleayed clearance

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4
Q

viral mophology mollucum contagiosum (pox virus)

A

ovoid to brick shaped

linear doubled standed DNA

rep;icate exlcuisvely in cytoplasm (carries all necessary proteins)

transmits via direct contact

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5
Q

treatment Chlamydia trachomatis

A

single dose IM ceftriaxone (to taget N gonorrhoeae)

7d course oral doxycycline or 1 oral dose azithromycin

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6
Q

presentation, dx and treatment candida albincans

A

vaginal itching and thick copious discarhge

increased incidence in antibiotic, new OBC, menses, pregnancy

dx via KOH prep

treatment Imidazole suppositories or single dose fluconazole

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7
Q

morphology gardnerella vaginalis

A

pleomorphic gram neg rods

not dependent on X factor or V factor for growth (as the simular haemophilus ducreyi is)

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7
Q

Jarisch Herxheimer Phenom

A

worsening of symptoms of T pallidum infxn after starting ABx due to pyrogen release by killed organism

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7
Q

Chalmydia tachomatis mrophology

cell target

A

gram negative

oblligate intracellular

ATP/ADP ranslocator usurbs host energy

tiny, not easily seen on gram stain

targets columnar epithelia cells at mucous membranes

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8
Q

presentation and diagnosis molluscum contagiosum

A

nodular wart like lesions

begin as papules and become ubillicated with central caseous plug

clusters of 5-20 nodules

Dx based on lesions and histology of large eosinopihllic cystoplasmic inclusions (mollluscum bodies)

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9
Q

Dx treponema pallidum

A

VDRL and RPR - abs against cardiolipin and lecithin release during bacterial damage (non-specific)

FTA-ABS - IFA to detect abs agasint T pallidum

PCR

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10
Q

Tertiary treponema palllidum:
Gummatous syphyllis =

cardiovascualr syphillis:=

neurosyphillis =

A

Gummatous syphyllis = - localied granulamouts lesions in skin/bones, noninfectious

cardiovascualr syphillis:= aneurysm in ascending aorta or arch, due to destruction of small arterioles supplying aorta

neurosyphillis = asymptomatic, subactue with fever, stiff neck, headache. Meningovascular with infarction due to ceerebral vessel damage. Tabes dorsales if spinal cord affected

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10
Q

presentation and dx, trichomonas vaginallis

A

most males asymptomatic, urethrtitis, prostatitis rare

scant watery discharge in females, posssible vaginitis+ painful urination

Dx via microscopy

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11
Q

dx chlamydia trachomatis

A

by elcusion

cytoplasmic inlcusions on giemsa stain or scarpings

PCR for DNA can be obtained from urine

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12
Q

presentation and dx garnerella vaginallis

A

part of normal flor

vaginitis,

prurititis, dysuria

prulent discharge with fishy ordor

dx with clue cells (multple pleomorphic bacterira in discharge)
Whiff test - amine odor when KOH added to sample

high PH

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13
Q

presentation and diagnosis haemophilus ducreyi

A

chancroid - tender papule with ertyhtmatous base

progresses to painful ulceration with assocd. LAD (unilateral)

dx based on culture, PCR of ulcer of lymph node aspiarates

13
Q

ureaplasma urealyticum morphology

A

mycoplasma family - no cell wells, (beta lactams and gram stain don’t work)

pleomorphic shape

urease breaks down urine into amonia > alakaline urine

14
Q

disease presentations Chlamydia trachomatis (5)

A
  • *Non gonococcal urethritis** - most commom STI, dysuria, mucoid discharge
  • *PID** - abnl vaginal discahrge, bloeeding, intense lower Adb pain
  • *chlamydial epididymitis** - unilateral scotal swelling, tenderness, pain
  • *lymphogranuloma venereum** - painless papule > heals. invades unilateral inguinal lymph nodes > drainprulent exudate through sinus tracks
  • *Reiter’s syndrome-** complication - arthritis, conjuncitivits, blanitis circinata, keratodermia blenorrhagia (scaly rash on palms and soles)
15
Q

Neisseria gonorrhea morphology

A

Gram neg dipplococci

oxidase positive

pili, outer membran porins (for invasion to epithelal)

opa proteins

iga proteast

LPS mediated destruction of cilia on neighboring cells

17
Q

treatment Ureaplasma urealyticum

A

erthromycin

tetracycline

18
Q

dx + presentation herpes simplex

A

HSV 1 or 2 specific antibodies

fevere

headaces

malaise

myalgias

LAD

19
Q

Diease presentation neisseria gonorrheae

dx

A

urethritis with painful urination

purulent discharge

epididiymiiis, prostatitis, urethral strictures

endocervictis, PID

bacteriemia +septic arthritis > extremity lesions, fever

dx via gram stain on Thayer Marter VCM

21
Q

presentation adn ddx ureaplasma urealyticum

A

carried by 60% healthy women

due to infection of lower UT

dyruria, yellow mucoid discharge

dx via pCR or culture (requires cholesterol and urea for growth)

tiny colonies (T-strain)

22
Q

treatment hameophilus ducreyi

A

azithromycin

ceftriaxone,

ciprofloxacin

23
Q

morpohlogy treponem a pallidum

A

gram negative spirochete

extra out membrane

perplasmic flagella

24
Q

treatment gardernella vaginallis

A

metronidazole (flagyl)

clindamycin)

26
Q

haemophilus decryi morphology

A

coccobacilli

facultative aneraobes

often associated with mucous membranes

27
Q

trichomonas vaginallis morphology

A

four flagella, undulating membrane

trophozoite only form

28
Q

treatment trichomonas vaginalis

A

metronidazole (flagyl)

tinidazole if resistant

30
Q

pathophys of PHV integration events

A

disrupt expression of viral E2 gene - negative regulato of viral e6 and 37 oncogenes

31
Q

HPV morphology and significant strains

A

papovirus, small circular DS DNA,

icosahedral, capsid, not eveloped

most genital caused by HPV 6 and 11

high risk 16 18 31 46

32
Q

treatment T pallidum

A

penicillin

ethrythromycin

doxycycline

33
Q

treatment Neisseria gonorrheae

A

IM ceftriaxone

(erthromycin eye drops prophylatic at birth)

34
Q

infection stages treponema pallidum

A

primary - chancre, highly infectious, painless

secondary - hematogenic sprea, rash, feve LAD,alopecia, highy contagious *condyloma latum * at moist sites

;atent - asymptomatic, noninfectious (except fetal)

tertiary - slow inflammaition driven damage to organs

Endocrine (45 decks)

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