Male fertility Flashcards
normal FSH indicates no significant _____ dysfunction
testicular
if sterile patient negative for CFTR/5T, then .. (testing)
renal U/S
why test estradiol?
T > estradiol via aromatase
high levels of aromatase in body fat
inheritance patern for CBAVD
most autosomal recessive
common defects when CFTR testing is negative
pathophys is these cases
renal abnormalities
mesonephric duct gives rise to uretal bud, SV, vas deferens, lower 2/3 of epididymus
defect in mesonephic duct early leads to agenesis of genital ducts and ipsilateral kidney
if low T, then…. (testing)
repeat T earlyi n AM
order LH, prolactin estradiol
common mutation pattern in CBAVD an cystic fibrosis patients
impact of mutations
most have 2 mutations
second most oftenon 5T alllele
casue involution of genital ducts during embryogenesis
spermatogenesis is fine
___d stem cell > spermatozoa
____days transit in epididymis
= ___d to reflect change in SA
70 days stem cell to spermatoza
20days transit epididymis
90 days to reflect change
most common cause of male infertility
examples
testicular
(varicoceles, gondatoxins, primary testicular problems)
initital evaluation of infertile male
Full H+P
Sereum analysis (>3)
Hormones (Total T, FSH, reserve LH, estradiol, prolactin if low T)
scrotal U/S if testicular gross abnl
