M3: Endocrine System Flashcards
In charge of producing and releasing hormones in order for the body to function
Endocrine system
Composed of a collection of organs and tissues that communicate with cells using chemical messengers called hormones
Endocrine system
The endocrine system is mainly a group of separate structures called ___________ ___________.
Endocrine glands
TRUE OR FALSE:
There are some organs and tissues that secrete hormones but are not considered glands.
TRUE.
The endocrine system is connected to the cardiovascular system by secreting hormones directly to the ___________ compared to the nervous system.
Bloodstream
___________ get to almost every cell in the body and usually takes longer to take effect than _________ (seconds to days).
Hormones; nerves
Chemically active compounds that are produced in one area of the body but have their effect on cells that they act upon (target cells)
Hormones
Cause an effect only in their specific target cells and can have many different target cells
Hormones
Are responsible for the many sequential changes of growth and maturation and is also agents of response when homeostasis is disrupted
Hormones
Other functions of hormones
- Maintain fluid balance
- Control calcium and glucose levels in the blood
- Assist in tissue repair
- Maintain basal metabolic rate
- Assist in digesting food
Endocrine glands in the body
- Hypothalamus
- Pituitary
- Pineal Gland
- Thyroid
- Parathyroid
- Thymus
- Adrenals
- Pancreas
- Ovaries (in females)
- Testicles (in males)
Two main classes of hormones
Steroid hormones and non-steroid hormones
Similar to cholesterol, a type of lipid; water-insoluble, lipid-soluble
Steroid hormones
Composed of amino acids; water-soluble, lipid-insoluble
Non-steroid hormones
Most receptors are located within the cytoplasm
Steroid hormones
Receptors are located on the cell membrane
Non-steroid hormones
Once bound to its specific receptors, the desired process takes up to a few minutes to many hours
Steroid hormones
Once bound to its specific receptors, the desired process immediately occurs
Non-steroid hormones
Two main classes of hormones
Glucocorticoid & Glucagon
STEROID HORMONE ACTIVITY:
The first phase of steroid hormone activity
The lipid-soluble hormone passes through the membrane and binds to its receptor, forming a hormone-receptor complex
STEROID HORMONE ACTIVITY:
The second phase of steroid hormone activity
The activated hormone-receptor complex initiates gene transcription
STEROID HORMONE ACTIVITY:
The third phase of steroid hormone activity
Messenger RNA leaves the nucleus and directs the formation of a new protein; this either upregulates or downregulates production of specific proteins.
STEROID HORMONE ACTIVITY:
The fourth phase of steroid hormone activity
The cell uses these new proteins, altering cell activity
STEROID HORMONES:
Produced by ovaries, testes, adrenal cortex
Androgens and estrogens
STEROID HORMONES:
Target cells include most cells of the body
Androgens and estrogens
STEROID HORMONES:
Stimulate the development of secondary sexual characteristics
Androgens and estrogens
STEROID HORMONES:
Produced by adrenal cortex
Mineralocorticoids
STEROID HORMONES:
Target cells are found in the kidneys
Mineralocorticoids
STEROID HORMONES:
Increase absorption of sodium and water by the kidneys; accelerate potassium loss
Mineralocorticoids
STEROID HORMONES:
Another hormone produced by the adrenal cortex
Glucocorticoids
STEROID HORMONES:
Another hormone alongside androgens and estrogens whose target cells also include most cells of the body
Glucocorticoids
STEROID HORMONES:
Promote liver formation of glucose and glycogen; release amino acids from muscle; anti-inflammatory effects
Glucocorticoids
STEROID HORMONES:
Produced by kidneys
Calcitrol
STEROID HORMONES:
Target cells are found in the intestinal lining
Calcitrol
STEROID HORMONES:
Stimulates calcium and phosphate absorption; inhibits parathyroid hormone (PTH levels)
Calcitrol
NON-STEROID HORMONE ACTIVITY:
The first phase
Binding of hormone to its receptor activates attached enzymes within the cell
NON-STEROID HORMONE ACTIVITY:
The second phase
cAMP from activated adenylate cyclase serves as a second messenger to activate protein kinases
NON-STEROID HORMONE ACTIVITY:
The third phase
Activated protein kinases phosphorylate cellular proteins
NON-STEROID HORMONE ACTIVITY:
The fourth phase
Millions of phosphorylated proteins cause reactions that produce physiological responses
NON-STEROID HORMONES:
Produced by the adrenal medulla
Epinephrine and norepinephrine
NON-STEROID HORMONES:
Target cells include most of the body
- Epinephrine and norepinephrine
- Insulin
NON-STEROID HORMONES:
Increase cardiac activity, blood pressure, and blood glucose levels; release stored lipids
Epinephrine and norepinephrine
NON-STEROID HORMONES:
Produced by the anterior pituitary
- Adrenocorticotropic hormone (ACTH)
- Growth hormone (hGH)
NON-STEROID HORMONES:
Target cells are found in the adrenal cortex
Adrenocorticotropic hormone (ACTH)
NON-STEROID HORMONES:
Stimulate secretion of glucocorticosteroids
Adrenocorticotropic hormone (ACTH)
NON-STEROID HORMONES:
- Produced by the pancreas
- Target cells are found in the liver and adipose tissues
Glucagon
NON-STEROID HORMONES:
Activate lipid reserves; elevates blood glucose
Glucagon
NON-STEROID HORMONES:
- Produced by the pancreas
- Promote uptake of glucose
- Stimulates lipid storage
Insulin
NON-STEROID HORMONES:
Promote growth, protein synthesis, lipid movement
Growth hormone (hGH)
NON-STEROID HORMONES:
Cause secretion of thyroid hormones (triiodothyronine & thryoxine)
Thyroid-stimulating (TSH)
NON-STEROID HORMONES:
Produced by the thyroid gland; increase energy utilization, oxygen consumption, growth, and development
Thyroxine
NON-STEROID HORMONES:
- Produced by the anterior pituitary
- Target cells are melanocytes
- Increase melanin pigment concentration
Melanocyte-stimulating hormone (MSH)
NON-STEROID HORMONES:
- Inhibit secretion of GnRH (gonadotropin-releasing hormone, which governs the release of FSH and LH)
- Produced by the pineal gland
- Target cells are found in the hypothalamus
Melatonin
NON-STEROID HORMONES:
- Produced by anterior pituitary
- Target cells are immature egg cells of ovary; interstitial cells of testes
- Either trigger ovulation in the ovary, or testosterone secretion in testes
Luteinizing hormone (LH)
NON-STEROID HORMONES:
- Produced by anterior pituitary
- Target cells are immature egg cells of the ovary; immature sperm cells of the testes
- Either stimulate egg development and production of estrogen, or facilitate sperm development
Follicle-stimulating hormone (FSH)
NON-STEROID HORMONES:
- Produced by testes, ovaries
- Target cells are found in the anterior pituitary gland
- Inhibit secretion of FSH
Inhibin
NON-STEROID HORMONES:
- Produced by hypothalamus
- Target cells are found in the uterus and mamary glands; vas deferens and prostrate glands
- Trigger smooth muscle contractions during labor, milk release, or sperm release
Oxytocin
NON-STEROID HORMONES:
- Produced by anterior pituitary
- Target cells are found in mammary glands
- Stimulate milk production
Prolactin (PRL)
NON-STEROID HORMONES:
- Produced by thyroid gland
- Target cells found in bone, kidneys
- Decrease calcium concentration in body fluids
Calcitonin
NON-STEROID HORMONES:
- Produced by parathyroid glands
- Target cells found in bone, kidneys
- Increase calcium concentration in body fluids
Parathyroid hormone
NON-STEROID HORMONES:
- Produced by hypothalamus
- Target cells found in kidneys
- Cause reabsorption of water for urine production; elevation of blood pressure
Antidiuretic hormone
NON-STEROID HORMONES:
- Produced by kidneys
- Target cells found in red bone marrow
- Stimulate production of red blood cells
Erythropoietin
Homeostasis is usually maintained via __________ ______________. This type of regulation applies to most hormones.
Negative feedback
A water-soluble hormone that prevents the secretion of growth hormone in the anterior pituitary
Somatostatin
Helps regulate digestive function in the abdominal cavity
Somatostatin
Prevents the pancreas from releasing hormones that regulate blood sugar
Somatostatin