Lymphoid Pathology Infectious diseases Flashcards
What is the gross and histopathology of a virus in the thymus?
- Gross- haemorrhage/ oedema
- Histopathology- Decreased number of lymphocytes in all major organs (lobular collapse in the thymus)
What is a notifiable virus for the thymus?
Classical Swine Fever
What are some important viruses in the pig industry?
- African Swine Fever (splenomegaly)
- Porcine circovirus
What is the gross pathology of haematropic bacteria?
Splenomegaly and Icterus
What is the histopathology of haematropic bacteria?
Congestion, erythrophagia, hemosiderosis (excessive amounts of iron in the tissues)
What do Pyogenic bacteria incite?
Neutrophils
What does the gross pathology of pyogenic bacteria look like?
Multifocal absesses, suppurative inflammation
What does the histopathology of pyogenic bacteria look like?
Abcesses in chronic
fribroneutrophillic inflammation in acute
What is a notifiable pyogenic bacterial disease?
Streptococcus equi.
What is a notfiable granulomatous bacterial disease?
Rhodoccoccus equi.
What is the gross pathology of granulomatous bacteria?
Granulomatous inflammation (just very hard)
What is another word for Mycobacterium avium ssp. paratuberculosis
Johne’s disease (notifiable in cattle)
What is the histopathology of infectious bacteria?
Multinucleated giant cells, granulomas (central core of necrosis?)
What would a spleen with Bacillus Anthracis look like?
Bloody spleen
What may caseous lymphadenitis look like?
caseous lymph nodes
What is the overview of how fungi affect the gross pathology?
- Meaty spleen
- Granulomatous inflammation
What is the histopathology of how fungi affects an organ?
Fungal structures
Cells full of Yeast
Granulomatous inflammtion
What is the gross pathology of protozoa?
- Meaty Spleen, splenomegaly, lympadenomegaly
- Granulomatous inflammation
- oedema/ haemorrhage
What is the histopathology of protozoa?
Granulomatous inflammtion with intralesional organisms
Lymphoid hyperplasia with systemic infections
lymphoid atrophy
What does babesia protozoa cause?
Splenic congestion, Icterus, anemia, hemoglobinuria
What is the usual gross pathology of autoimmune diseases?
Splenic congestion, icterus, anemia, lympadenomegaly
What is the usual histopathology of autoimmune diseases?
- Follicular hyperplasia
- Bone marrow can either be depletion or hyperplasia
- Splenic histiocytosis
What is the overview of neoplastic lymphoma?
- Most common haemotologic malignancy in dogs
- Classified due to its anatomical location
What is the gross pathology of neoplastic lymphoma?
Enlargement of organ- megaly (thickening of the intestines)
Pale tan nodules that bulge on the cut section
What is the histopathology of neoplastic lymphomas?
- Proliferation of lymphocytes (either monomorphic or pleomorphic)
- You can use nuclear size and mitotic count to determine the type of lymphoma
What is PARR used for/ used to determine?
used for lymphomas to confirm clonality
What are the common antibodies that an IHC will pick up to test for a T Cell?
CD3+
What are the common antibodies that an IHC will use to test for a B cell?
CD20+, CD79a+
What type of Virus is Feline Leukemia virus?
Gammaretrovirus
What are the disease syndromes of feline leukaemia virus?
neoplasms, bone marrow supression, neurologic disorders
What organs does bovine leukemia virus commonly affect?
Lymph nodes, abomasum, heart, spinal cord, kidney, uterus
What may a splenic neoplasia Hemangiosarcoma look like histologically?
endothelial cells produce poorly formed vascular areas
What is the overview of SCID?
- Developmental disease
- Deficiency in B cells and or T cells
- Most common in arabian horses (mutation in DNA-PKcs gene)
What is the gross pathology of SCID?
small thymus, spleen- hyperplasia
What is the histopathology of SCID?
Decreased or absent T cells and or B cells in lymphoid tissues (hypoplasia)
What other disease is SCID commonly associated with?
Bronchopneumonia
What do siderotic plaques look like grossly?
grey-white to yellow, firm, dry encrustations multifocally scattered across the splenic capsule
What do siderotic plaques look like histologically?
Capsular deposits of billirubin, hemosiderin, hematoidin and/or calcium
What does streptococcus equi cause?
Strangles
What does rhodococcus equi cause?
pyrogranulomatous lymphadenitis
