Lymphoid Pathology Infectious diseases Flashcards

1
Q

What is the gross and histopathology of a virus in the thymus?

A
  • Gross- haemorrhage/ oedema
  • Histopathology- Decreased number of lymphocytes in all major organs (lobular collapse in the thymus)
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2
Q

What is a notifiable virus for the thymus?

A

Classical Swine Fever

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3
Q

What are some important viruses in the pig industry?

A
  • African Swine Fever (splenomegaly)
  • Porcine circovirus
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4
Q

What is the gross pathology of haematropic bacteria?

A

Splenomegaly and Icterus

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5
Q

What is the histopathology of haematropic bacteria?

A

Congestion, erythrophagia, hemosiderosis (excessive amounts of iron in the tissues)

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6
Q

What do Pyogenic bacteria incite?

A

Neutrophils

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7
Q

What does the gross pathology of pyogenic bacteria look like?

A

Multifocal absesses, suppurative inflammation

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8
Q

What does the histopathology of pyogenic bacteria look like?

A

Abcesses in chronic
fribroneutrophillic inflammation in acute

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9
Q

What is a notifiable pyogenic bacterial disease?

A

Streptococcus equi.

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10
Q

What is a notfiable granulomatous bacterial disease?

A

Rhodoccoccus equi.

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11
Q

What is the gross pathology of granulomatous bacteria?

A

Granulomatous inflammation (just very hard)

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12
Q

What is another word for Mycobacterium avium ssp. paratuberculosis

A

Johne’s disease (notifiable in cattle)

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13
Q

What is the histopathology of infectious bacteria?

A

Multinucleated giant cells, granulomas (central core of necrosis?)

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14
Q

What would a spleen with Bacillus Anthracis look like?

A

Bloody spleen

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15
Q

What may caseous lymphadenitis look like?

A

caseous lymph nodes

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16
Q

What is the overview of how fungi affect the gross pathology?

A
  • Meaty spleen
  • Granulomatous inflammation
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17
Q

What is the histopathology of how fungi affects an organ?

A

Fungal structures
Cells full of Yeast
Granulomatous inflammtion

18
Q

What is the gross pathology of protozoa?

A
  • Meaty Spleen, splenomegaly, lympadenomegaly
  • Granulomatous inflammation
  • oedema/ haemorrhage
19
Q

What is the histopathology of protozoa?

A

Granulomatous inflammtion with intralesional organisms
Lymphoid hyperplasia with systemic infections
lymphoid atrophy

20
Q

What does babesia protozoa cause?

A

Splenic congestion, Icterus, anemia, hemoglobinuria

21
Q

What is the usual gross pathology of autoimmune diseases?

A

Splenic congestion, icterus, anemia, lympadenomegaly

22
Q

What is the usual histopathology of autoimmune diseases?

A
  • Follicular hyperplasia
  • Bone marrow can either be depletion or hyperplasia
  • Splenic histiocytosis
23
Q

What is the overview of neoplastic lymphoma?

A
  • Most common haemotologic malignancy in dogs
  • Classified due to its anatomical location
24
Q

What is the gross pathology of neoplastic lymphoma?

A

Enlargement of organ- megaly (thickening of the intestines)
Pale tan nodules that bulge on the cut section

25
Q

What is the histopathology of neoplastic lymphomas?

A
  • Proliferation of lymphocytes (either monomorphic or pleomorphic)
  • You can use nuclear size and mitotic count to determine the type of lymphoma
26
Q

What is PARR used for/ used to determine?

A

used for lymphomas to confirm clonality

27
Q

What are the common antibodies that an IHC will pick up to test for a T Cell?

A

CD3+

28
Q

What are the common antibodies that an IHC will use to test for a B cell?

A

CD20+, CD79a+

29
Q

What type of Virus is Feline Leukemia virus?

A

Gammaretrovirus

30
Q

What are the disease syndromes of feline leukaemia virus?

A

neoplasms, bone marrow supression, neurologic disorders

31
Q

What organs does bovine leukemia virus commonly affect?

A

Lymph nodes, abomasum, heart, spinal cord, kidney, uterus

32
Q

What may a splenic neoplasia Hemangiosarcoma look like histologically?

A

endothelial cells produce poorly formed vascular areas

33
Q

What is the overview of SCID?

A
  • Developmental disease
  • Deficiency in B cells and or T cells
  • Most common in arabian horses (mutation in DNA-PKcs gene)
34
Q

What is the gross pathology of SCID?

A

small thymus, spleen- hyperplasia

35
Q

What is the histopathology of SCID?

A

Decreased or absent T cells and or B cells in lymphoid tissues (hypoplasia)

36
Q

What other disease is SCID commonly associated with?

A

Bronchopneumonia

37
Q

What do siderotic plaques look like grossly?

A

grey-white to yellow, firm, dry encrustations multifocally scattered across the splenic capsule

38
Q

What do siderotic plaques look like histologically?

A

Capsular deposits of billirubin, hemosiderin, hematoidin and/or calcium

39
Q

What does streptococcus equi cause?

A

Strangles

40
Q

What does rhodococcus equi cause?

A

pyrogranulomatous lymphadenitis