lung cancer - paraneoplastic features Flashcards
what can be used to differentiate between SC and NSC lung cancer
bronchoscopy
small cell secretes
ADH ACTH
what is lambert eaton syndrome associated with
SCLC
what is lambert eaton syndrome
involves hyporeflexia, proximal limb weakness and reduced autonomic activity
ACTH produced where and release in response to what
pituitary gland stress
what can excess ACTH production cause
cuhsing syndrome - ACTH controls corticosteroid production
what ar some CF of cushings syndrome
moon face
buffalo hump
what does SCLC responsd well do
chemotherapy
what is large cell
diagnosis of exclusion
large cell - peripheral or central?
peripheral
pathology of large cell
necrosis and haemorrhage frequent and acute/chronic inflammation
what does squamous cell secrete
PTH-rp
what does PTH-rp secretion lead to
hypercalcaemia
what does PTH do
controls the distribution Ca and phosphate in the body, high PTH level causes Ca to leave the bone for blood.
squamous - central or peripheral
central
adenocarcinoma - central or peripheral
peripheral
what type of lung lesion is squamous
cavitating
what is squamous associated with
HPOA
HPOA
combined clubbing and periostitis of the small hand joins
what does squamous produce
keratin pearls also maybe thyroid transcription factor
what is the antigen of squamous
p63
and high molecular weight cytokeratins
what group is adenocarcinoma common in
non smokers
what does adenocarcinoma form
mucous secreting glands
immunhistochemistry of adenocarcinoma
TTF1 expressed
what clinical feature can adenocarcinoma cause
gynaecomastia
bronchioalveolar carcinoma
spread of adenocarcinoma along alveolar walls
what is squamous metaplasia
The initial stage in tumour development where cells gross appearance and histological findings are altered but there is no malignancy
what is carcinoma in situ
the final stage in tumour development before becoming malignant
