long term memory complete Flashcards

1
Q

what is semantic knowledge

A

general world knowledge that humans have accumulated throughout their life

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2
Q

2 basic facts about memory and the NS

A

in order for there to be a memory, there has to be a physical change in the NS

diff parts of brain are responsible for diff types of memory, nonetheless, memory is quite pervasive in the nervous system, hard to find a part of the NS that doesn’t have some capacity for learning and memory

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3
Q

we make an alaogy of memory to computer systems because both share an

A

common underlying representation, in the case of memories in the NS, that representation is in the connections between neurons , and how strong those connections are

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4
Q

___ maintenance for short term memory

______ storage for long term memories

A

Active maintenance for short term memory

Passive storage for long term memories

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5
Q

3 differences between computers and our brains in this analogy

A

parts of machines that store memories are physically distinct from the parts that do the actual work (processing) hard drives vs central processing unit for example - NOT how the NS works,

in a computer you can have a pattern of 1s and 0s and copy it from place to place easily through cloud email etc, same pattern means the same thing, in the brain you can’t move memories around in the same way, the meaning of a memory, as encoded by connections between neurons is fundamentally tied to which neurons we are talking about,

In a computer primary way memories are accessed is based on their location - you look info up by specific physical location on a chip or disc, in Human Memory - accessed based on a cue - based on its content

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6
Q

4 processes required for memory to work

A

Encoding - has to be encoded into the brian in a way that can be put into memory

Consolidation - initial coding often changes over time if we keep a memory around

Storage - at some point the memory is stored, hopefully sticks around

Retrieval - accessing info from stored information traced

Reconsolidation - possible reorganization of memory traces after retrieval. Can get rewritten from retrieving it,

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7
Q

how do we use dissociation to look at the extent to which one system or the other can be damaged

A

If you are able to show damage to one part of the brain is associated with one process, damage to another part is associated to a diff process - gives you evidence that they are 2 different systems

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8
Q

memory span tasks test _____

A

short term memory

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9
Q

list learning task test ____

A

long term memory

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10
Q

how does the memory span task work

A

you have a sequence of words and the example here is 3 words - time, base, offer. Your job is to try to recite them back in the same order as accurately as you can. Number of words cna differ but that is the basics of the task - immediate recall in correct order

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11
Q

how does the list learning task work

A

you hear a longer sequence of words (10) and then you are to recall them and it can be in ANY ORDER, if you don’t get them all right you get to hear them all again, try to recite them again, do it until you can recite the whole list correctly

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12
Q

what is a single dissociation

A

a patient who is impaired on one task but not all, is a Single Dissociation

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13
Q

explain the partial damage argument for dissociations

A

maybe there is only one system being used to perform BOTH tasks, and maybe this patient has partial damage to that system - because the short term memory task is Harder than the long term one the partial damage has led to a drop in performance on the harder tasks - but is intact enough to complete the easier one

explains the single diss without saying there must be 2 distinct brain systems

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14
Q

explain the compensation argument for single dissociations

A

maybe the damage knocked out a single system that would normally be used for both tasks - but because the short term task is harder, the participant has found a way to compensate for the easier task but not for the harder one

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15
Q

what brain damage did HM have

A

temporal lobes bilaterally

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16
Q

what gives us the Double Dissociation

A

This crossover pattern with 2 patients with damage to 2 distinct brain areas with opposite patterns of impairment on 2 tasks gives us our

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17
Q

short term vs long term mmeory - which has more capacity

A

Short term memory is extremely LIMITED (7 words in task)

wheres LT is massive in comparison (20000 words in vocab)

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18
Q

short and long term memory are represented in different ways

A

LT memory seems to be based on the strength of connections between neurons as well as NUMBER of connects

ST is represented by WHICH neurons are currently active in the brain - sometimes neurons can maintain that activity for at least a few seconds

different physical bases in the brain for these two - current activity VS structural connections

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19
Q

what is the perceptual identification task and what type of memory is it used to test

A

used for implicit memory

study phase - words are flashed on a screen for 2 secs each, one after the other -

test - identify the word as fast as you can - some you have seen before some are new - is it easier to ID the ones you have seen before

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20
Q

what memory type was the word recognition task test

A

Explicit
study phase you see 24 words flashed for 2 seconds each

test phase - you are again get a mix of old and new words at random, each word appears on screen and stays as long as you need in order to respond yes it was in first phase or no it is a new word - here you are explicitly asked if they are new words or if you already saw them.

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21
Q

how does the MS patient do in the explicit word recognition task and the implicit perceptual identification task

A

Now by comparison you can look at the performance of MS patient (damage to right occipital lobe) they do NOT show a priming effect in perceptual id task they are impaired, BUT they are able to Explicitly recall the words as well as the control group

they have a Single Dissociation between Implicit and Explicit Memory
not neough to prove anything

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22
Q

how do the amnesia patients do on the explicit word recogniton task

A

they are impaired on the explicit word recognition task, but show a priming effect if anything larger effect as it helps them more

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23
Q

how is the double dissociation shown in the implicit and explicit tasks

A

we put the MS patient and the Amnesia patient together - they both have damage to different places - strong evidence that implicit and explicit memory are distinct processes that depend on diff parts of the brain

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24
Q

explicit memory

A

declarative, things we can remembr and bring to mind

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25
Q

the two kinds of non assocaitive memory are

A

habituation and sensitization

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26
Q

describe habituation

A

response decreasing with repetiton

hearing the fan until you get used to it

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27
Q

describe sensitization

A

response to unchanging stimulus repeated becomes increased over time

someone rubs your hand and it starts to hurt

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28
Q

what does sensitization involve - pathway

A

sensory motor reflex pathways

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29
Q

what is presynaptic depression

A

the neural basis behind Habituation

sensory neuron fires the same AP every time it is touched, releases less NT over time causing the EPSP goes down if the presynaptic motor neuron becuase less receptors take up the NT

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30
Q

presynaptic facilitation

A

neural basis of sensitization

AP of sensory neuron stays the same, but over time it releases MORE neurotransmitters, causing the EPSP in the motor neuron to increase

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31
Q

what are the long term effects of habituation and sensitization

A

an increase or decrease betwen the sensory and motor neurons

32
Q

in pavlov’s dog
what is the unconditioned stim
the unconditioned response
the conditioned stim
the conditioned response

A

US - food
UR - salivation
CS - bell
CR - salivation

33
Q

descirbe the rat fear cond study on simple terms

A

If you play a tone for the mouse it doesn’t have a response at first, on other hand if you give the animal a light shock to its feet done through the surface of the cage, the animal will freeze in response. The shock is the uncon stim, and freezes is uncon response. If we now pair tone and shock together and then test the animal again by tone by itself, we find the animal freezes in response to tone.

34
Q

for the fear cond rat study, we have audio stimulus and somatosensory stimulus - where do they converge

A

tone and shock converge on the Lateral Nucleus of Amygdala - as this area is critical for fear conditioning

35
Q

in the rat study looking at fear cond, why are EPSPs represented by a dip in the curve

A

because they are measured form outside neurons, if neuron has positive effect then + ions flow into the neurons to create the EPSP, and the outside becomes more negative

36
Q

what response does the lateral nucelus of amygdala to the tone when it is paired with a shock vs not paired

A

same tone played, same AP’s in incoming sensory cells, but leads to different effects on the cells in the LN of Amygdala that create larger EPSP’s in response after pairing the tone with the shock

37
Q

in the rat tone shock study - where does the fear conditioning occur

A

in the lateral nucleus of the amygdala

38
Q

there are two kinds of implicit/procedural memory

what are they - and what part of the brain are they involved in

A

Motor Adaption - depends on cerebellum

Sequence Learning - involves CorticioBasalGangliaThalamicCocortica Loops

39
Q

what study reflects motor adaptation in the CB

what is this process called

A

dart study

person hits dart
puts on prism glasses - misses dart
learns to compensate and hits dart
removes glasses - misses dart
compensates to reality - hits dart

Adaptation

40
Q

what would someone with a damaged CB do in the dart study

what does this suggest

A

hit dart
put on glasses - miss dart
don’t adapt to glasses
remove glasses - hits dart
doesn’t take time for them to adjust to reality because they never adapted to the glasses

suggests profound lack of motor adaptation in absense of a functioning CB - no feedback loop that corrects them

41
Q

describe the study that shows how motor sequence learning works

A

participant with a set of buttons, when you see a light you push matching button fast
get a sequence of them
if you get the same sequence twice, you can do it faster, even if you don’t recognize that you have done this sequence before

42
Q

how do you know what actions to take and when

A

BG loops are trained via reinforcement learning

positive and negative prediction errors

believed to be controlled by Dopamine from substantia nigra - burst of it strenghthens direct pathway, and inhibits indirect pathway

43
Q

how does dopamine have diff effects on the two pathways

A

Dopamine from substantia nigra - burst of it strengthens direct pathway, and inhibits indirect pathway

possible because each has receptors that react differently to dopamine

44
Q

what is priming

A

situations where being exposed to a stimulus leads you to later think about either that same stimulus or something similar even without being aware of that priming. Can take a few different forms.

45
Q

3 diff kinds of priming

A

conceptual - meaning of the word
semantic - words of related meanings
perceptual - gollin photos that show the whole picture gradually, amnesia patients

46
Q

conceptual priming

A

based on MEANING on the word -

Primed with a word envelope, now

going to present dif words to you and you have to think of related words.
He says cue is stationary - what words are related - you find you are more likely to think of envelope

47
Q

semantic priming

A

Primed with word envelope but now imagine that a bit later you are doing a task where you list words starting with S.

you say stationing, it comes to mind faster having recently seen an envelope than if you hadn’t recently seen an envelope.

Here the thing that is coming to mind is not the exact word that was primed but another word related in meaning.

Think of it like if you are primed with something it activates not only the word envelope itself, but also primes other related words like paper, letter, or note.

48
Q

perceptual priming

A

gollin pictures - start w fragments and have to guess what the photo is

do this amnesia patients

come back the next day and they can tell faster what it is even though they don’t remember doing it before

49
Q

describe the semantic priming task

A

similar to lexical task

given a prime, then delay, then a sequence of letters - have to say if htey create a word or not

in one trail the word is related to the target, in others not.

people could say faster if it is a word or not based on if it iwas related to the target

seeing the word primes you of related words as well

50
Q

where does priming happen in the brain

A

Cortex

perceptual priming involves sensory as well
but the rest are higher up in areas that deal with semantics and categories
- anterior temporal, inferior parietal, prefrontal cortex etc

51
Q

where in the brain is semantic memory

name to the theoriies

A

Sensory Functional Theory - in the cortex, organized by sensory functional features of words
- words based on sensory, visual, auditory features and motor features bell - audio, kick in motor area of legs, pick motor arm area,

Domain Specific Theory - based on semantic categories - one area for fruits, one for veggies,

52
Q

how can we reconcile these two diff theories of cortex organization
domain specific vs sensory functional

A

data for both - activations are categorical, but they also sensory functional in organization because item sin categories tend to be correlated in their sensory and functional features (tool and actions, animals and how they look

likely to some extend that both of these theories have some truth to them

53
Q

how do we end of with semantic memories - representations of meaning

A

we learn about world through episodic memory - after what we learn is ingrained well enough - the information becomes semantic, and we can’t remember the episodic memory of learning it

54
Q

the encoding of episodic memory depends on 2 brain structures, has 2 key aspects to it - describe the process

A

HippoCampus & Medial Temporal Lobes (glue)

the ind. representations of the halloween party - sam, elmo - have prior experience with them

Hippo - binds ind representations together into a specific epi memory of the event

55
Q

retrieval of episodic memory - halloween party

A

a friend says remember the party? mentions sam and elmo, causing the representations for those to be activated in our semantic representations in Cortex
also functions as cue for the HC binding to come active too

sam and cue = cues for whole memory to come back

56
Q

describe the movement of semantic representation via cortex. mtl, HC

A

semantic representation in the cortex - unimodal and polymodal association areas

when they become active they are fed down into the MTL - via Perihinal and ParaHippoCampal Cortices

and into the HC via Entorhinal Cortex

Entorhinal is a pathway into HC proper

Semantic Representations have flown into HC through the following steps, but we need a way for into to get back out so the HC reps can activate cortical representation

57
Q

what does the fornix do

grey or white matter

A

main output pathway that connects both side of HC together and also connects HC up to other parts of the brain

a white matter tract

58
Q

spatial role of medial temporal lobes and the study where they discovered it

theory of this is called, cells active in this are called….

A

Cognitive Map Theory

rat in maze, track where it is, while recording ind neurons in MTL - keep track of when they fire and create map of where animal was each time it does

see these cells MTL is active based on where the animal is - so theyre named ‘Place Cells’

59
Q

besides the cognitive map theory - what else did they learn the MTL can do via what kind of study?

A

Relational Memory Theory of MTL

Odour associatioin task - animal has to pair diff odours over each other following a general rule they have to apply to diff situations

One can do it well, the other group has Lesioned Fornix - their primary output pathway from HC and MTL is disrupted, so they can do the basic task, but not when they relate it to a more complicated situation

proves there is a General Associational Component of MTL as well as spatial - the relational memory theory

60
Q

what does the Perihinal Cortex do

A

feeds the ‘system’ of MTL,

specialized for representing the bindings between features that form objects (colour, shape, taste of fruit) - object coding

61
Q

what does the ParaHippoCampal Cortex do

A

similar to perihinal but focused on representations of where things are relative in space - banana and grape on a fruit plate - spatial coding

62
Q

both the feature data from perirhnial c and the spatial data from parahippo cortex are fed into the

A

hippocampus that binds all these aspects together into the overall memory

63
Q

neurons that fire together wire together - is the jist of what kind of learning

A

Hebbian

64
Q

hebbian learning in neurons - overview

A

presyn neuron fires resulting in post nueron fires - strengh of that synpatic connection is increased - next time presyn fires it is more likely postsyn will too

65
Q

what mechanism in the brain implements the process of hebbian learning

what two terms C and A are related to this principle

A

if all 3 neurons fire and collectively cause an AP in the output - we get LTP and Connectivity

image one of them has previous connection and it firing alone is enoguh to cause AP, but it happens that the 2nd neuron fires AP at the same time - but its just along for the ride - we get Associativity

if 1 and 3 fire and 2 dont - LTP only occurs at the synapses that were involved in generating the AP

66
Q

early ltp and late ltp

A

early - strengh of exising synapses created by increase of NT release and number of functional receptors on other side

late - increase in number of synapses between the two neurons

67
Q

if presynaptic neuron fires an post one doesn,t there is a weakening of connection between the 2 neurons - what is this called - what are the 2 phases

A

long term depression

early - reduction in amount of NT released and less functioning receptors on other side

late - fewer synapses between the two over time

helps stop runaway lop of positive feedback

68
Q

reconstruction refers to __ in waht kind of memory

A

when we think about episodic memories we often change the memory based on current goals and thought

69
Q

study that shows reconstruction

A

memroize list of words related to sleep

see words after and try to say yes or no if they were on the list or not - one of them is related to sleep, but not on the list but since its related we say yes and feel confident it was part of the original list - lure words

70
Q

list 5 reasons for error in reconstruction

A

Semantic Relatedness - why the sleep one makes sense

Past Cultural Experiences - remember things in a way consistent to what usually happens in our day to day life

Source MisAttributions - say a friend tells us something we missed during an event, later on we may think we saw it ourselves

Pragmatic Inferences - see a work shop, later someone asks if we saw a hammer we say yes cause that would be likely

Misleading PostEvent Info - given info after an event can influence our memory

71
Q

how does Consolidation work

A

forming a new epi memory requires HC and Cortex (ind reps)

over time due to revisitn gmemory, sleep, gradually links between diff portions of mem start to get formed in cortex itself - depends less on HC

72
Q

how does consolidation process explain HM’s memory loss

A

his HC was removed - so recently formed mems not yet consolidated were lost, childhood ones consolidated were not

no HC - couldn’t form any new memories

73
Q

describe complementary learning systems hypothesis - why have both the HC and Cortical System

A

HC - learn quickly from single event - distinct memories

Cortical - learning generalities over time from repeated events

animal wants to know where to fruit tree is HC, also wants to know what a fruit tree is, what fruit to eat etc Cortex

both are important

74
Q

do childhood events become semantic?

A

yes if you here them enough they are more like general knowledge of what happened and less clear memories of the event - grandpa telling story example

starts as episodic, through repetitioin becomes a more semantic cortical memory - less of a first person memory tied to a time or place

grey area here

75
Q

is consolidation permanent

A

no because retireval makes a memory flexibe to be rewritten - inference or loss

76
Q

rat study shown of reconsolidation
why did this work

A

day 1 - pair rat w tone and shock and it freezes
day 2 - play tone, no shock, rat freezes, inject memory block drug
day 3 - play tone and rat doesn’t freeze -

why? memory was retrieved on day 2 and wasn’t reconsolidated so the memory was lost
memroy is rewritten all the time