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GI > Liver Biochemistry > Flashcards

Liver Biochemistry Flashcards

1
Q

Where are plasma proteins produced?

A

the liver:

  • abumin
  • alpha, beta and gamma globulins
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2
Q

What are the functions of plasma proteins?

A
  • maintain oncotic or colloid osmotic pressure
  • trasnport hydrophobic substances (steroid hormones, free fatty acids, bilirubin cholesterol)
  • pH buffers
  • enzymes
  • immunity
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3
Q

What is the main determinant of plasma oncotic pressure?

A

Albumin

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4
Q

Functions of Albumin?

A

-Transport (fatty acids, bilirubin, hydrophobic hormones, hydrophobic drugs)

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5
Q

How is iron transported in the blood?

A

-as Fe3+ (ferric iron) bound to transferrin

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6
Q

How is iron stored in cells?

A

Bound to ferritin.

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7
Q

What is the Cu transporter protein?

A

Ceruloplasmin

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8
Q

Liporotein lipid transporters?

A

Chylomirons, VLDL, IDL, LDL, HDL

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9
Q

Chylomicrons?

A

carry exogenous (dietery) fat to the liver

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10
Q

VLDL?

A

transport endogenous (dietary) fat to peripheral tissues

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11
Q

IDL?

A

LDL precursor

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12
Q

LDL

A

transports cholesterol to peripheral tissues

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13
Q

HDL?

A

transports cholesterol from the bloodstream to the liver

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14
Q

What is cholesterol a precursor of?

A

bile acids
steroid hormones
viamin D

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15
Q

Essential for cholesterol synthesis?

A

Acetyl-CoA
NADPH
ATP

HMG-CoA reductase in the liver

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16
Q

What drugs target HMG-CoA reductase?

A

Statins

17
Q

Caeruloplasmin is deficient in…

A

Wilson’s disease

18
Q

What is the role of caerulopasmin?

A
  • Copper transport in blood

- transport and use of iron

19
Q

What is the carrier protein of thyroxine?

A

Thyroid-binding globulin

20
Q

What is the carrier protein of cortisol?

A

Cortisol-binding globulin

21
Q

What viramins are stored by the liver?

A

Vitamin A, D and B12

GI (36 decks)

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