Crohn's disease - pathology Flashcards
1
Q
Crohn’s disease presents with…
A
abdo pain small bowel obstruction diarrhoea bleeding PR anaemia weight loss
2
Q
Appearance on endoscopy?
A
- Cobble stone appearance
- patchwork/segmented pattern
- ‘skip lesions’ - interspersed normal and diseased areas
3
Q
Histological appearance?
A
- disruption of crypt architecture
- granulomas formation
- increased cells of chronic inflammation
4
Q
Crohn’s disease affects…
A
all the areas of the bowel wall (mucosa, submucosa, muscularis propria) - it is a transmural process
5
Q
Complications of Crohn’s?
A
fistulas
anal disease (sinuses, fissures, abscesses)
obstruction
pre-malignant
6
Q
Ulcerative Colitis?
A
Chornic inflammation confined to the colon and rectum.
Inflammation of mucosa and submucosa of the colon
aetiology is unknonwn
7
Q
Ulcerative colitis always involves…
A
the rectum.
The disease progresses up the colon in a conitinuous manner (key difference from Crohn’s)
8
Q
UC symptoms?
A
diarrhoea, mucous and blood on PR
9
Q
Which layers are affected in UC?
A
mucosa and submucosa
superficial ulcers may be present
10
Q
Complications of UC?
A
intractable disease toxic megacolon (can rupture) colorectal carcinoma
