LFTS Flashcards

1
Q

best liver function test

A

trick questions! none!!

most informative if used as a group and looking for patterns of abnormalities

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2
Q

damage to bile duct seen in which LFT (3)

A
  1. alkaline phosphatase
  2. 5’nucleotidase
  3. bilirubin- severe
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3
Q

damage to hepatocyte seen in which LFT (6)

A
  1. AST/ALT
  2. protein synthesis
  3. immunoglobins
  4. removal of ammonia- severe
  5. clotting factors- severe
  6. glucose homeostasis- severe
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4
Q

increase in unconjugated bilirubin (2)

A
  1. hemolysis

2. UGT1A1 deficiency: (a) Gilbert’s (b) crigler-najjar

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5
Q

increase in conjugated bilirubin (2)

A
  1. Dubin-Johnson syndrome (MRP-2)

2. Hepatocyte injury

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6
Q

which bilirubin is soluble in water and excreted in urine

A

conjugated

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7
Q

serum ammonia used to diagnose

A

hepatic encephalopathy or urea cycle disorders

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8
Q

hypoalbuminemia can be due to

A

chronic liver disease. protein malnutrition

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9
Q

liver produces all clotting factors except for

A

Factor VIII

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10
Q

what is the single best measure of hepatic synthetic function

A

factor VII

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11
Q

AST and ALT are indicators of

A

hepatocyte injury

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12
Q

which is more specific for the liver ALT or AST

A

ALT

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13
Q

relative levels of ALT and AST

what about in alcoholic liver disease

A
  1. ALT > AST

2. alcohol-induced deficiency of pyridoxal phosphate which impairs synthesis of ALT more than of AST

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14
Q

what if the GGT are elevated?

A

less specific and both ER or bile duct cells might be affected

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15
Q

diffuse polyclonal increases sin IgG seen in

A

autoimmune hepatitis

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16
Q

elevated alpha-fetoprotein

A

since it is produced by hepatocytes sit might be an indication of hepatocellular carcinoma or hepatic injury or liver regenetation

17
Q

what can we see in hepatocellular

A
  1. ALT, AST elevations

2. hepatitis, vascular injury, drugs

18
Q

what can we see in cholestatic

A
  1. alkaline phosphatase elevation

2. bile duct obstruction, PBC, PSC, tumor

19
Q

what can we see in severe liver disease acute/chronic

A
  1. low albumin

2. elevated bilirubin

20
Q

what can we see in liver failure

A
  1. elevated PT

2. low glucose