histo Flashcards
esophageal squamous cell carcinoma- These cancers can be ulcerating and fungating lesions. They are usually located in the mid or proximal esophagus. They are not associated with Barrett’s esophagus
esophageal adenocarcinoma- These are usually fungating, ulcerating masses that are found in the distal esophagus at the gastroesophageal junction. They are usually associated with Barrett’s esophagus and histologically are gland-forming tumors.
areas of ulceration and multinucleated giant cells in herpetic esophagitis.
normal esophageal motility study
hirschsprung disease
tumor invades through muscularis propria into subserosal fat- T3
total colectomy from 18 yr old with FAP syndrome showing innumerable adenomatous polyps
sessile serrated adenomatous polyp- notice the weird shape of the stalks
adenomatous polyps- villous with high grade dysplasia
adenomatous- villous
adenomatous polyps- tubular adenoma
hyperplastic polyps- low or non malignant potential look at the nice v shape of the stalks
PSC-ECRP this disease is diagnosed by either MRCP or ERCP findings
hereditary hemochromatosis
alcoholic liver disease- notice the extensive mallory bodies
cirrhosis-trichrome stain
chronic viral hepatitis- notice the fibrosis around the bile triad and how it is spreading and to another triad
lymphocytic microscopic colitis- notice the lymphocytes, there is a lot of them
collagenous microscopic colitis- notice the thick collagen ban
crohns- transmural inflammation and ulcer
ulcerative colitis- notice that the inflammation is confined to the mucosa, there are crypt abscess and gland distortion
ulcerrative colitis- mucosal layer affected only
Crohns- notice the deep ulcerations
celiac disease- villous atrophy, increased lymphocytes in intra-epithelial layers and lamina propria
chronic pancreatitis
acute pancreatitis CT scan
chronic gastritis with intestinal metaplasia
achalasia
schatzki ring
eosinophilic esophagitis
Barrett’s mucosa- specialized intestinal metaplasia wiht goblet cells and columnar cells
carcinoid tumor of small bowel
steatorrhea in chronic pancreatitis- Fat malabsorption in chronic pancreatitis is due to decreased secretion of lipase and colipase
The diagnosis of chronic pancreatitis is difficult early in the disease as tests for pancreatic insufficiency are uncomfortable and difficult to obtain and imaging of the pancreas may not show definitive signs of calcifications and duct abnormalities
Chronic pancreatitis slowly progresses. Over time the symptoms change from the early presentation with chronic abdominal pain to later signs of malabsorption and diabetes
pathology of chronic pancreatitis- pancreatic duct is filled with a mucin plug and there are chronic inflammatory cells lymphocytes scattered in the duct and surrounding parenchyma
Bisap score for the severity of acute pancreatitis
This is a microscopic section of pancreas from a patient with acute interstitial pancreatitis. The pancreatic acinar architecture, best seen on the left half of the image, is preserved. Much of the right half of the slide shows saponified fat w
gastric adenocarcinoma-signet ring cell type-linitis plastica
gastric mass seen on plain chest-x-ray and ulcerated mass in stomach on endoscopy
upper endoscopy- mass in gastric antrum consistent with gastric adenocarcinoma
peptic ulcer pathology- normal gastric epithelium on either side of disrupted epithelium with ulcer crater
upper endoscopy- ulcer in duodenal bulb with visible vesse
upper endoscopy- ulcers in duodenal bulb
upper endoscopy- antrum with ulcers arrow on largest ulcer
Atrophic gastritis. Normal gastric epithelial elements have been replaced by intestinal type epithelium in the center and upper right aspect of the image
acute and chronic inflammation of H pyloric
HP organisms brown stain in gastric pits
Acute gastritis. The gastric mucosa is infiltrated by inflammatory cells, including a prominent number of neutrophils- Some of the neutrophils are present in
