Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

GI > inflammatory bowel disease > Flashcards

inflammatory bowel disease Flashcards

1
Q

mucosal ulceration in the colon

A

ulcerative colitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

transmural inflammation

A

chron’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

equal incidence between chron’s and ulcerative

A

yep

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what type of cells are granulomas made off

A

histiocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

IBD genetics:

  1. ATG16L1 and NOD2
  2. IRGM
  3. IL23-R
A
  1. autophagy related-process of segregation and disposal of damaged organelles within a cell is impaired leading to bacteria/antigens triggering immune response
  2. immunity relateed GTPase which increases risk for Chrons
  3. interleukin-23 receptor which leads to increased risk for chrons and certain populations with UC
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

ulcerative colitis:

  1. symptoms
  2. location
  3. serologic testing
  4. pseudopolyps
  5. histo
  6. acute complication
  7. natural course of disease
  8. increased risk as times goes on
  9. what do see endoscopally
A
  1. bloody diarrhea, nocturnal diarrhea
  2. always starts at the rectum and continues sequentially through the colon
  3. positive P-ANCA
  4. finger like projections of residual normal mucosa
  5. inflammation is confined to the mucosa with crypt abscess, gland distortion and dysplastic crypts with no goblet cells
  6. toxic megacolon
  7. intermittent
  8. colorectal cancer- colorectal adenocarcinoma
  9. erythmea, punctuate ulcerations
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

3 different types of chrons

A
  1. inflammatory
  2. obstructive
  3. fistulizing
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

string sign

A

chrons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

cobblestone appearance

A

chrons, parts that is healing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

chron’s skip lesions

A

chrons manifestation is through segmental involvement and not continuous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

perineal disease

A

chrons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

nearly 80% of patients with chrons require surgery

A

yep

  • but recurrence is common within 6 year after surgery
  • it is a chronic illness with flares and remissions
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

positive ASCA

A

chrons disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

osteoporosis in IBD

A

it happens!! incidence is about 20-30% and it can happen with or without corticosteroid use

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

complication of IBD specific to pediatric population

A

growth failure and delayed sexual development

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

surgery in IBD

  1. ulcerative colitis
  2. chrons
A
  1. panproctocolectomy due to failure of med therapy, dysplasia
  2. directed to specific complications
17
Q

nutritional therapy in IBD

  1. best nutritional source
  2. parenteral
  3. enteral
  4. repleting vitamin deficiency
A
  1. food
  2. not a primary therapy for either
  3. primary therapy in chrons
  4. vit. D, calcium, vit. B12 especially in chrons
18
Q

pro-inflammatory cytokines

A

TNFAlpha and IL-12

19
Q

is rectal bleeding more common in UC or CD

A

UC

20
Q

frequent small volume diarrhea with urgency

A

UC

21
Q

abdominal pain localized to the right lower quadrant

A

CD

22
Q

endoscopically, deep ulcers with skip lesions

A

CD

23
Q

pathology shows cryptitis with crypt abcess and branching of crypts

A

both

24
Q

pathology shows granulomas

A

CD

25
Q

almost 90% chance of recurrence of disease after surgery

A

CD

26
Q

chronic inflammatory disease of the colon where the etiology is unclear but us linked to several medications such as NSAIDs, PPIs, sertraline/SSRIs and ranitidine

A

microscopic colitis

27
Q

diagnosis of microscopic colitis

A

colonoscopy with random biopsies from right and left side of the colon that will show lymphocytic colitis >10 or collagenous colitis with increased thick colonic subepithelial collagen band and increased intraepithelial lymphocytes

28
Q

type of diarrhea with microscopic colitis (2)

A
  1. chronic, persisten, non-bloody watery diarrhea

2. nocturnal diarrhea, decal incontinence

29
Q

treatment for microscopic colitis

  1. mild
  2. mild to severe
A
  1. low residue diet and pepto
  2. oral budesonide that works topically on the colon

*** eliminate offending medications

30
Q

ischemic bowel disease occurs most commonly in the

A

colon

31
Q

chronic ischemia can present with ulcers and strictures and thus resembles

A

chrons disease

32
Q

ischemic bowel disease pathology

  1. acute
  2. organizing
  3. healed
A
  1. acute- hemorrhage in lamina propria, epithelial coagulative necrosis
  2. organizing- granulation tissue and fibrosis
  3. healed- atrophy, shortened crypts, branched glands

GI (26 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions