Lesson 14 Flashcards
Act as the same site as the neurotransmitter acetylcholine
Cholinergic agonist
Increase the activity of ACH (acetylcholine)
Cholinergic agonist
These receptor sites are found throughout the body, so their stimulation produces similar effects when the parasympathetic nervous system is activated
Parasympathomimetics
Give examples of indirect-acting cholinergic agonists
Alzheimers Disease
Myasthenia Gravis
Similar to ach and react directly with receptor sites to cause the same reaction
Direct-acting Cholinergic Agents
Common examples of Direct-acting Cholinergic Agonist
Bethanechol and pilocarpine
Used as agents to increase bladder tone, urinary excretion, and GI secretions
Direct-acting Cholinergic Agonist
Used to treat non-obstructive postoperative and pospartum urinary retention to treat neurogenic bladder atony
Bethanechol
An opthalmic agent use to induce miosis or pupil constriction
Carbachol
Betanechol is approved for treatment of neurogenic bladder in children _____
Older than 8 years of age
Bind to muscarinic receptors and used to increase secretion in the mouth and gI tract and relieve symptoms of dry mouth
Cevimeline and pilocarpine
Used to control myasthenia gravis and for reversal of neuromuscular junction
Neostigmine
Pyridostigmine
Used for diagnosis of myasthenia gravis
Edrophonium
Do not react directly with ACH receptor sites
Indirect-acting cholinergic agonist
They react chemically chemically with acetylcholinesterase
Non-directing cholinergic agonist
Enzyme breaking down acetylcholine
Acetylcholinesterase
The ones bind irreversibly are not used therapeutically, they are being developed as
Nerve gas to be used as weapons
The antidote for indirect-acting cholinergic agonist
Pralidoxime
Two main categories of Non-directing cholinergic agonist
Agents used to treat myasthenia gravis
Agents used to treat alzheimers disease
React with the enzyme acetylcholinesterase
Non-directing cholinergic agonist
These agents increase the levels of acetylcholine
Agents for myasthenia gravis
This agent cause elevated ACH levels in the cortex
Agents for Alzheimers disease
Non-directing cholinergic agonist should be orally administered by?
Empty stomach
Drugs that oppose the affects of acetylcholine
Anticholinergics
They lyse and block the effects of parasympathetic nervous system
Parasymphatolytics
Currently the only widely used anticholinergic drugs
Atropine
It used to decrease GI activity and secretions
Anticholinergics
Basically erosions in the lining of GIT caused by increased HCL production
GI ulcer
GI ulcer is commonly caused by
H. Pylori infection
Competitively blocking thE ACH receptors
Anticholinergics
Atropine, a protoype drug, derived from the plant ______
Belladonna
Used to depress salivation and bronchial secretions and to dilate the bronchi
Atropine
Work by blocking only muscarinic effe ctors in the parasympathetic nervous system
Atropine
Scopolamine
