Lecture 34: Macrocyclic Lactones Flashcards
are macrocyclic lactones cidal or static
Cidal
Macrocyclic lactones have activity against both ___ and ___
Nematodes and ectoparasites
What avermectins are for use in food animals
Ivermectin, eprinomectin, doramectin
What milbemycin is approved for use in food animals
Moxidectin
What avermectins are for use in small animals
Selamectin, ivermectin
What milbemycins are approved for use in small animals
- Moxidectin- dogs only
- Milbemycin oxime
What spinosyn is approved for use in small animals
Spinosyn A/D
What avermectins is approved for use in horses
Ivermectin
What milbemycin is approved for use in horses
Moxidectin
Topical macrocyclic lactones are more effective against ___
Biting lice
What macrocyclic lactones are effective against horn flies in ruminants
Ivermectin and eprinomectin
What does ivermectin tx in pigs
GI roundworms, lungworms, lice, sarcoptic mange
What is ivermectin and Moxidectin use for in horses
GI roundworms
Ivermectin in horses has better activity against ___
Gastrophilus intestinalis (bots)
Moxidectin in horses has better activity against ___
Cyanthostomum (GI round worms)
What is ivermectin use for in dogs
- Prevention of D. Immitis
- Generalized demodicosis, Cheyletiella (zoonotic), sarcoptes scabieie, otodectes, pneumonyssoides spp
What is selamectin used for in dogs
- Prevention of D. Immitis
- Fleas
- Otodectes spp
- Sarcoptes scabiei
- Dermeacentor variabilis
What is milbemycin oxime effective against in dogs
- D. Immitis prevention
- GI round worms
- Hookworms (zoonotic)
- Whipworms
What is Moxidectin used for in dogs
- Prevention D. Immitis
- Hookworms only
What is spinosad effective against in dogs
Fleas
All macrocyclic lactones are effective against stage __ and __ larvae of D. Immitis
Stage 3 and 4
What is ivermectin used for in cats
Prevention of D. Immitis
What is selamectin used for in cats
- Prevention of D. Immitis
- Fleas
- Otodectes spp
- T. Cati
- A tubaeforme (hookworms)
What is milbemycin oxime effective against in cats
- D. Immitis prevention
- GI roundworms
- Hookworms
What is spinosad used for in cats
Fleas (dosing is higher than in dogs)
What is class 1 heart worm disease on severity scale
Asymptomatic, positive antigen test
What is class 2 heart worm disease on severity scale
Moderate pulmonary damage, coughing, exercise intolerance
What is class 3 heart worm disease on severity scale
right CHF, cor pulmonale, syncope, anemia, cache is
What is class 4 heart worm disease on severity scale
= caval syndrome
Shock, DIC, jugular distention, mitral regurgitation
What classes on severity scale for heart worm disease can be treated with drugs
1-3