Lecture 32: Anti-Nematode Agents Flashcards
What is the life cycle for nematodes
- Ingestion of larvae/eggs
- Migration and maturation in host
- Elimination of egg/ larvae
- Ingestion eggs by host
4a. Ingestion/ infection by intermediate host
5a. Consumption or vectoring
6a. Ingestion by definitive host
What is fenbendazole approved for in dogs
Roundworms, hookworms, whipworms
What is fenbendazole approved for in cats
Roundworms, hookworms, strongyloides, lungworms and Giardia
What is fenbendazole approved for in cows
Lungworms, stomach worms, intestinal worms
What is fenbendazole used for in horses
Strongyles, pinworms, ascarids
Febantel is a prodrug that is metabolized to ___following absorption
Fenbendazole
What is febantel indicated for
Dogs: roundworms, hookworms, whipworms
Cats: roundworms, hookworms, strongyloids, lung worms, Giardia
What is albendazole approved for cats and dogs
Giardia
What is albendazole approved for in cows
Stomach worms, intestinal worms, lung worms
What is levamisole indicated for in cattle (beef and non-lactating dairy), sheep’s and goats
- Mature and larval lung worms
- Mature stages of GI worms
What is levamisole approved for in swine
Mature stages of GI worms
Levamisole parent compound is broken down into what 2 compounds
- I-tetramisole-levamisole: anti-nematodal effects, toxicity
- D-tetramisole- no anti-nematodal effects, toxicity
What is the Pd of levamisole
- NM agonist- causes tetanic paralysis- worms unable to maintain attachment to host
Levamisole paralyzes worms but still alive when excreted in feces so important that owner ___
Picks up feces otherwise reinfection
Levamisole is best absorbed when given ___
SQ
Levamisole is not to be used in what animals and why
Lactating dairy cattle- enters milk of cattle 1hr following SQ administration
Levamisole is metabolized in ___
Liver
How levamisole eliminated
60% in urine, 30% in feces