Lecture 22: Inhibitors of Protein Synthesis II Flashcards
what is the mechanism of action of tetracyclines
Inhibition of protein synthesis by inhibiting 50s ribosomes and prevent access of aminoacyl TNRA to receptor site on mRNA-ribosome complex
Are tetracyclines bacteriostatic or bacteriocidal
Bacteriostatic
Are tetracyclines narrow or broad spectrum
Broad
Tetracycline have antimicrobial activity against what organisms
Gram positive and negative aerobes, anaerobes, Ricketssia (such as Anaplasma, Haemobartonella), spirochetes, mycoplasma clamydiae and some protozoans
Uptake of tetracyclines is ___dependent so they poorly penetrate ___
Oxygen, anaerobes
What are some uses for tetracyclines/ which ones in large animals
Tetracycline, chlortetracycline and oxytetracycline are used in treatment of local and systemic bacterial, chamydial, rickettsial and protozol infections in cattle, swine and sheep and as feed additives/ growth promoters in cattle, swine and poultry
What are some uses for tetracyclines in small animals/which ones
Doxycycline, minocycline, and tetracycline used for respiratory and urinary tract infections in dogs and cats, specific therapy for Boreilla (Lyme), brucella, haemobartonella, adn Ehrlicha
Also tx coccidiosis in birds
What tetracyclines have shown to be effective in abscesses in cats that don’t respond to B-lactams
Doxycycline and minocycline
Tetracyclines treat what special condition in foals and what is MOA
Contracted tendons in foals, inhibit the collagen based contraction in myofibroblasts
What is the drug of choice in treating tick borne diseases in animals
Doxycycline
What tick borne diseases does doxycycline tx in cats
Mycoplasma and chlamydophilia Felis
What tick borne diseases does doxycycline tx in dogs
Ehrlichia canis
What drug is often added to heart worm tx against Wolbachia
Doxycycline
Oral and parentally administered tetracyclines should be avoided in ___ due to danger in disrupting ___ or __ microflora
Horses, ruminal or colonic
Divalent and trivalent cations impair absoprtion of tetracyclines therefore ___, ___ and ___, should be avoided 3hrs before and after oral adminsitration
Milk, antacids, iron salts
What tetracyclines are more lipid soluble and distribute to CNS, eyes, and prostate
Doxycycline and minocycline
Which tetracycline is extensively metabolized by the liver
Minocycline
What is the route of elimination for doxycycline
Intestinal excretion
How long is the withdrawal period after intrauterine administration of oxytetracycline in cattle. What do they also recommend
28 days
Also recommends milk testing
What is the withdrawal period of IM or SQ administration of oxytetracycline in goats or sheep. And what is milk withdrawal time
28 days
Milk withdrawal 96 hrs