Lecture 3: Aspergillus Flashcards
Fungal serologic testing is good but ___can make interpretation difficult
historical exposure
Fungal __is very good, but can get false positives
PCR
fungal histology is good but ___is more sensitive and specific
immunohistochemistry
what does A. Fumigatus cause in dogs and cats
sinonasal disease
what breeds of dog are more susceptible to aspergillus infection
doliocephalic breeds
what does A. Fumigatus cause in birds
air sacculitis
what does A. Fumigatus cause in horses
guttural pouch mycosis
what is an adverse effect of A. Flavus
hepatoxicity- aflatoxin
what are some clinical signs of sinonasal disease in dogs and cats
chronic mucopurulent nasal discharge
how do you dx sinonasal dz in dogs and cats
histopathology, rhinoscopy, imaging, serology, culture
what is tx for sinonasal disease caused by A. Fumigatus in dogs and cats
- Surgical debridement and topical azoles
- Topical azoles
- Oral azoles
what birds is A. Fumigatus causing air sacculitis common in
turkeys, chickens, raptors, penguins, parrots
what are some clinical signs of air sacculitis caused by A. Fumigatus
respiratory +/- systemic disease/ CNS
air sacculitis caused by A. Fumigatus has a __morbidity and mortality
high
what are some causes of air sacculitis caused by A. Fumigatus
moldy feed and bedding material
how do you dx air sacculitis in birds
presence of lesions
why is tx of air sacculitis caused by A. Fumigatus in birds difficult
due to lack of approved antifungals and low margin of safety in food animals
how do you prevent air sacculitis caused by A. Fumigatus
clean bedding, replace feed, decrease stress and concurrent immunosuppression
from bird- presented with respiratory signs. You examine food and notice there is mold present. What is likely dx and cause
Air sacculitis caused by A. Fumigatus
what are some signs of guttural pouch mycosis
- Chronic URI- nasal discharge, epistaxis
- CNS signs- dysphasia, horners syndrome
how do you dx guttural pouch mycosis
history, clinical signs, endoscopy
what is tx for guttural pouch mycosis
angiographic guided embolization- coil targets internal carotid artery and blocks blood flow
what is the SIR model
susceptible—> infected—> recovered or dead
what is the environmental persistence model of disease transmission
environmental exposure contributing to who is susceptible—>infected—> recovered or dead
aspergillus mycosis is na fungal __ not a fungal __
infection, intoxication
calculate morbidity rate: 75 sick, 125 dead, total population 500
morbidity rate= sick +dead/total
75+ 125/500=40%
calculate mortality rate: 75 sick, 125 dead, 500 total population
Mortality rate: dead/total population
125/500=0.25 25%
calculate case fatality rate: 75 sick, 125 dead, 500 total population
case fatality rate: dead/sick +dead
125/ 75+125=126.667 62.5%
