Lecture 3: Aspergillus

Question 1

Fungal serologic testing is good but ___can make interpretation difficult

Answer 1

historical exposure

Question 2

Fungal __is very good, but can get false positives

Answer 2

PCR

Question 3

fungal histology is good but ___is more sensitive and specific

Answer 3

immunohistochemistry

Question 4

what does A. Fumigatus cause in dogs and cats

Answer 4

sinonasal disease

Question 5

what breeds of dog are more susceptible to aspergillus infection

Answer 5

doliocephalic breeds

Question 6

what does A. Fumigatus cause in birds

Answer 6

air sacculitis

Question 7

what does A. Fumigatus cause in horses

Answer 7

guttural pouch mycosis

Question 8

what is an adverse effect of A. Flavus

Answer 8

hepatoxicity- aflatoxin

Question 9

what are some clinical signs of sinonasal disease in dogs and cats

Answer 9

chronic mucopurulent nasal discharge

Question 10

how do you dx sinonasal dz in dogs and cats

Answer 10

histopathology, rhinoscopy, imaging, serology, culture

Question 11

what is tx for sinonasal disease caused by A. Fumigatus in dogs and cats

Answer 11

1. Surgical debridement and topical azoles
2. Topical azoles
3. Oral azoles

Question 12

what birds is A. Fumigatus causing air sacculitis common in

Answer 12

turkeys, chickens, raptors, penguins, parrots

Question 13

what are some clinical signs of air sacculitis caused by A. Fumigatus

Answer 13

respiratory +/- systemic disease/ CNS

Question 14

air sacculitis caused by A. Fumigatus has a __morbidity and mortality

Answer 14

high

Question 15

what are some causes of air sacculitis caused by A. Fumigatus

Answer 15

moldy feed and bedding material

Question 16

how do you dx air sacculitis in birds

Answer 16

presence of lesions

Question 17

why is tx of air sacculitis caused by A. Fumigatus in birds difficult

Answer 17

due to lack of approved antifungals and low margin of safety in food animals

Question 18

how do you prevent air sacculitis caused by A. Fumigatus

Answer 18

clean bedding, replace feed, decrease stress and concurrent immunosuppression

Question 19

from bird- presented with respiratory signs. You examine food and notice there is mold present. What is likely dx and cause

Answer 19

Air sacculitis caused by A. Fumigatus

Question 20

what are some signs of guttural pouch mycosis

Answer 20

1. Chronic URI- nasal discharge, epistaxis
2. CNS signs- dysphasia, horners syndrome

Question 21

how do you dx guttural pouch mycosis

Answer 21

history, clinical signs, endoscopy

Question 22

what is tx for guttural pouch mycosis

Answer 22

angiographic guided embolization- coil targets internal carotid artery and blocks blood flow

Question 23

what is the SIR model

Answer 23

susceptible—> infected—> recovered or dead

Question 24

what is the environmental persistence model of disease transmission

Answer 24

environmental exposure contributing to who is susceptible—>infected—> recovered or dead

Question 25

aspergillus mycosis is na fungal __ not a fungal __

Answer 25

infection, intoxication

Question 26

calculate morbidity rate: 75 sick, 125 dead, total population 500

Answer 26

morbidity rate= sick +dead/total

75+ 125/500=40%

Question 27

calculate mortality rate: 75 sick, 125 dead, 500 total population

Answer 27

Mortality rate: dead/total population
125/500=0.25 25%

Question 28

calculate case fatality rate: 75 sick, 125 dead, 500 total population

Answer 28

case fatality rate: dead/sick +dead

125/ 75+125=126.667 62.5%